Seroatlas · Human Serome Atlas

ZFP2

Zinc finger protein ZFP2

Also known as: FLJ21628, ZFP2_HUMAN, ZNF751

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZN57
Gene: ZFP2
Ensembl: ENSG00000198939
Chromosome: 5
Canonical length: 461 aa
Protein class: Predicted intracellular proteins, Transcription factors

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

461 residues, UniProt reviewed canonical sequence.

>Q6ZN57|ZFP2
     1  MEREGIWHST LGETWEPNNW LEGQQDSHLS QVGVTHKETF TEMRVCGGNE FERCSSQDSI
    61  LDTQQSIPMV KRPHNCNSHG EDATQNSELI KTQRMFVGKK IYECNQCSKT FSQSSSLLKH
   121  QRIHTGEKPY KCNVCGKHFI ERSSLTVHQR IHTGEKPYKC NECGKAFSQS MNLTVHQRTH
   181  TGEKPYQCKE CGKAFHKNSS LIQHERIHTG EKPYKCNECG KAFTQSMNLT VHQRTHTGEK
   241  PYECNECGKA FSQSMHLIVH QRSHTGEKPY ECSQCGKAFS KSSTLTLHQR NHTGEKPYKC
   301  NKCGKSFSQS TYLIEHQRLH SGVKPFECNE CGKAFSKNSS LTQHRRIHTG EKPYECMVCG
   361  KHFTGRSSLT VHQVIHTGEK PYECNECGKA FSQSAYLIEH QRIHTGEKPY ECDQCGKAFI
   421  KNSSLTVHQR THTGEKPYQC NECGKAFSRS TNLTRHQRTH T

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZFP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 6.3 nTPM

Expression across tissuesHPA

Tissue

retina: 6.3 nTPM
cerebellum: 6.1 nTPM
testis: 4.6 nTPM
ovary: 4.2 nTPM
colon: 3.7 nTPM
cerebral cortex: 3.6 nTPM

Single-cell type

bergmann glia: 30 nCPM
oligodendrocyte progenitor cells: 30 nCPM
oligodendrocytes: 26 nCPM
ependymal cells: 24 nCPM
pituitary stem cells: 23 nCPM
adrenal medulla cells: 21 nCPM

Immune cell

gdT-cell: 0.9 nTPM
memory B-cell: 0.9 nTPM
memory CD8 T-cell: 0.7 nTPM
naive CD4 T-cell: 0.7 nTPM
memory CD4 T-cell: 0.6 nTPM
T-reg: 0.5 nTPM

Brain region

cerebellum: 12 nTPM
white matter: 12 nTPM
midbrain: 9.8 nTPM
basal ganglia: 9.1 nTPM
cerebral cortex: 9 nTPM
hypothalamus: 9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.74
gnomAD pLI: 0
gnomAD missense Z: 0.03
DepMap mean gene effect: 0.14
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZFP2 as an antibody target. Whether an autoantibody or antibody against ZFP2 could matter depends on whether native ZFP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZFP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZFP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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