Seroatlas · Human Serome Atlas

ZFP14

Zinc finger protein 14 homolog

Also known as: KIAA1559, ZFP14_HUMAN, ZNF531

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9HCL3
Gene
ZFP14
Ensembl
ENSG00000142065
Chromosome
19
Canonical length
533 aa
Protein class
Predicted intracellular proteins, Transcription factors
Subcellular location
Nuclear speckles

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within blastocyst hatching. Predicted to be located in membrane. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

533 residues, UniProt reviewed canonical sequence.

>Q9HCL3|ZFP14
     1  MAHGSVTFRD VAIDFSQEEW EFLDPAQRDL YRDVMWENYS NFISLGPSIS KPDVITLLDE
    61  ERKEPGMVVR EGTRRYCPDL ESRYRTNTLS PEKDIYEIYS FQWDIMERIK SYSLQGSIFR
   121  NDWECKSKIE GEKEQQEGYF GQVKITSEKM TTYKRHNFLT EYQIVHNGEK VYECKECRKT
   181  FIRRSTLSQH LRIHTGEKPY KCKECGQAFR QRAHLIRHHK LHTGEKPYEC KECGKAFTVL
   241  QELTQHQRLH TGEKPYECKE CGKAFRVHQQ LARHQRIHTG EKPYECKDCG KTFRQCTHLT
   301  RHQRLHTAEK LYECKECGKA FVCGPDLRVH QKIHFGEKPY ECKECGKAFR ICQQLTVHQS
   361  IHTGEKPYEC KECGKTFRLR QQLVRHQRIH TREKPYECME CWKTFSSYSQ LISHQSIHIG
   421  ERPYECEECG KAFRLLSQLT QHQSIHTGEK PYECKECRKP FRLLSQLTQH QSIHTGEKPY
   481  ECKECGKAFR LYSFLTQHQR IHTGEKPYKC KECKKAFRQH SHLTQHQKIH NGI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZFP14 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.44
Highest tissue expression
8.3 nTPM

Expression across tissuesHPA

Tissue

  • retina: 8.3 nTPM
  • epididymis: 4.9 nTPM
  • cerebellum: 4.8 nTPM
  • parathyroid gland: 4.5 nTPM
  • spinal cord: 4.4 nTPM
  • thyroid gland: 4.1 nTPM

Single-cell type

  • rod photoreceptor cells: 101 nCPM
  • tuft cells: 92 nCPM
  • retinal bipolar cells: 77 nCPM
  • oligodendrocytes: 76 nCPM
  • bergmann glia: 72 nCPM
  • thyrotrophs: 67 nCPM

Immune cell

  • memory B-cell: 8.1 nTPM
  • naive CD8 T-cell: 6.6 nTPM
  • naive CD4 T-cell: 6.5 nTPM
  • naive B-cell: 6 nTPM
  • basophil: 5.7 nTPM
  • memory CD8 T-cell: 5.6 nTPM

Brain region

  • white matter: 23 nTPM
  • choroid plexus: 20 nTPM
  • cerebellum: 18 nTPM
  • hypothalamus: 17 nTPM
  • basal ganglia: 16 nTPM
  • medulla oblongata: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.74
gnomAD pLI
0
gnomAD missense Z
2.08
DepMap mean gene effect
0.1
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZFP14 as an antibody target. Whether an autoantibody or antibody against ZFP14 could matter depends on whether native ZFP14 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZFP14 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZFP14 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZFP14. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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