Seroatlas · Human Serome Atlas

ZFP1

Zinc finger protein 1 homolog

Also known as: FLJ34243, ZFP1_HUMAN, ZNF475

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6P2D0
Gene: ZFP1
Ensembl: ENSG00000184517
Chromosome: 16
Canonical length: 407 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

This gene belongs to the zinc finger protein family. Some members of this family bind to DNA by zinc-mediated secondary structures called zinc fingers, and are involved in transcriptional regulation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]

Canonical amino-acid sequenceUniProt

407 residues, UniProt reviewed canonical sequence.

>Q6P2D0|ZFP1
     1  MNKSQGSVSF TDVTVDFTQE EWEQLDPSQR ILYMDVMLEN YSNLLSVEVW KADDQMERDH
    61  RNPDEQARQF LILKNQTPIE ERGDLFGKAL NLNTDFVSLR QVPYKYDLYE KTLKYNSDLL
   121  NSNRSYAGKQ TDECNEFGKA LLYLKQEKTH SGVEYSEYNK SGKALSHKAA IFKHQKIKNL
   181  VQPFICTYCD KAFSFKSLLI SHKRIHTGEK PYECNVCKKT FSHKANLIKH QRIHTGEKPF
   241  ECPECGKAFT HQSNLIVHQR AHMEKKPYEC SECGKTFAQK FELTTHQRIH TGERPYECNE
   301  CAKTFFKKSN LIIHQKIHTG EKRYECSECG KSFIQNSQLI IHMRTHTGEK PYECTECGKT
   361  FSQRSTLRLH LRIHTGEKPY ECSECGKAFS RKSRLSVHQR VHIGEKP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZFP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 10 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 10 nTPM
liver: 10 nTPM
basal ganglia: 9.1 nTPM
cerebellum: 9.1 nTPM
amygdala: 8.5 nTPM
hippocampal formation: 8 nTPM

Single-cell type

cone photoreceptor cells: 19 nCPM
myonuclei: 14 nCPM
oligodendrocytes: 12 nCPM
brain excitatory neurons: 12 nCPM
other brain neurons: 11 nCPM
hepatocytes: 11 nCPM

Immune cell

NK-cell: 1.9 nTPM
memory CD8 T-cell: 1.7 nTPM
T-reg: 1.7 nTPM
MAIT T-cell: 1.6 nTPM
naive B-cell: 1.6 nTPM
gdT-cell: 1.5 nTPM

Brain region

white matter: 13 nTPM
cerebral cortex: 12 nTPM
basal ganglia: 12 nTPM
cerebellum: 11 nTPM
hippocampal formation: 11 nTPM
spinal cord: 10 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.71
gnomAD pLI: 0.01
gnomAD missense Z: -0.91
DepMap mean gene effect: 0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZFP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZFP1 as an antibody target. Whether an autoantibody or antibody against ZFP1 could matter depends on whether native ZFP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZFP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZFP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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