ZFAND3
AN1-type zinc finger protein 3
Also known as: FLJ13222, TEX27, ZFAN3_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9H8U3
- Gene
- ZFAND3
- Ensembl
- ENSG00000156639
- Chromosome
- 6
- Canonical length
- 227 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Vesicles
OverviewNCBI Gene
Predicted to enable DNA binding activity and zinc ion binding activity. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
227 residues, UniProt reviewed canonical sequence.
>Q9H8U3|ZFAND3
1 MGDAGSERSK APSLPPRCPC GFWGSSKTMN LCSKCFADFQ KKQPDDDSAP STSNSQSDLF
61 SEETTSDNNN TSITTPTLSP SQQPLPTELN VTSPSKEECG PCTDTAHVSL ITPTKRSCGT
121 DSQSENEASP VKRPRLLENT ERSEETSRSK QKSRRRCFQC QTKLELVQQE LGSCRCGYVF
181 CMLHRLPEQH DCTFDHMGRG REEAIMKMVK LDRKVGRSCQ RIGEGCSLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ZFAND3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.6
- Highest tissue expression
- 115 nTPM
Expression across tissuesHPA
Tissue
- skeletal muscle: 115 nTPM
- testis: 109 nTPM
- tongue: 63 nTPM
- blood vessel: 63 nTPM
- parathyroid gland: 53 nTPM
- liver: 50 nTPM
Single-cell type
- late spermatids: 5,205 nCPM
- neutrophils: 4,125 nCPM
- neutrophil progenitors: 1,563 nCPM
- endometrial glandular cells: 1,497 nCPM
- early spermatids: 1,451 nCPM
- monocytes: 1,210 nCPM
Immune cell
- eosinophil: 6.2 nTPM
- neutrophil: 6 nTPM
- plasmacytoid DC: 2.9 nTPM
- naive B-cell: 1.9 nTPM
- classical monocyte: 1.7 nTPM
- intermediate monocyte: 1.7 nTPM
Brain region
- medulla oblongata: 103 nTPM
- hypothalamus: 93 nTPM
- white matter: 92 nTPM
- midbrain: 92 nTPM
- spinal cord: 88 nTPM
- pons: 84 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.38
- gnomAD pLI
- 0.92
- gnomAD missense Z
- 1.38
- DepMap mean gene effect
- -0.17
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Molecular functions
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ZFAND3 as an antibody target. Whether an autoantibody or antibody against ZFAND3 could matter depends on whether native ZFAND3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ZFAND3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ZFAND3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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