Seroatlas · Human Serome Atlas

ZFAND2A

AN1-type zinc finger protein 2A

Also known as: AIRAP, ZFN2A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N6M9
Gene: ZFAND2A
Ensembl: ENSG00000178381
Chromosome: 7
Canonical length: 145 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable zinc ion binding activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and protein targeting to ER. Predicted to act upstream of or within cellular response to arsenic-containing substance and positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Predicted to be located in nucleus. Predicted to be part of proteasome complex. Predicted to be active in endoplasmic reticulum. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

145 residues, UniProt reviewed canonical sequence.

>Q8N6M9|ZFAND2A
     1  MEFPDLGKHC SEKTCKQLDF LPVKCDACKQ DFCKDHFPYA AHKCPFAFQK DVHVPVCPLC
    61  NTPIPVKKGQ IPDVVVGDHI DRDCDSHPGK KKEKIFTYRC SKEGCKKKEM LQMVCAQCHG
   121  NFCIQHRHPL DHSCRHGSRP TIKAG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZFAND2A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 78 nTPM

Expression across tissuesHPA

Tissue

liver: 78 nTPM
bone marrow: 76 nTPM
cerebral cortex: 58 nTPM
amygdala: 55 nTPM
hippocampal formation: 53 nTPM
spinal cord: 52 nTPM

Single-cell type

oocytes: 3,864 nCPM
pancreatic duct cells: 615 nCPM
epididymal principal cells: 419 nCPM
esophageal apical cells: 223 nCPM
colonocytes: 182 nCPM
pancreatic acinar cells: 173 nCPM

Immune cell

basophil: 72 nTPM
T-reg: 40 nTPM
naive B-cell: 35 nTPM
plasmacytoid DC: 35 nTPM
eosinophil: 34 nTPM
NK-cell: 33 nTPM

Brain region

cerebral cortex: 67 nTPM
white matter: 46 nTPM
hippocampal formation: 39 nTPM
cerebellum: 39 nTPM
hypothalamus: 36 nTPM
pons: 36 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.69
gnomAD pLI: 0
gnomAD missense Z: -0.95
DepMap mean gene effect: 0.09
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

zinc ion binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZFAND2A as an antibody target. Whether an autoantibody or antibody against ZFAND2A could matter depends on whether native ZFAND2A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZFAND2A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZFAND2A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...