Seroatlas · Human Serome Atlas

ZER1

Protein zer-1 homolog

Also known as: C9orf60, Hzyg, ZER1_HUMAN, ZYG, ZYG11BL

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z7L7
Gene: ZER1
Ensembl: ENSG00000160445
Chromosome: 9
Canonical length: 766 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

This gene encodes a subunit of an E3 ubiquitin ligase complex that may be involved in meiosis. The encoded protein contains three leucine-rich repeat motifs. [provided by RefSeq, Nov 2012]

Canonical amino-acid sequenceUniProt

766 residues, UniProt reviewed canonical sequence.

>Q7Z7L7|ZER1
     1  MASDTPESLM ALCTDFCLRN LDGTLGYLLD KETLRLHPDI FLPSEICDRL VNEYVELVNA
    61  ACNFEPHESF FSLFSDPRST RLTRIHLRED LVQDQDLEAI RKQDLVELYL TNCEKLSAKS
   121  LQTLRSFSHT LVSLSLFGCT NIFYEEENPG GCEDEYLVNP TCQVLVKDFT FEGFSRLRFL
   181  NLGRMIDWVP VESLLRPLNS LAALDLSGIQ TSDAAFLTQW KDSLVSLVLY NMDLSDDHIR
   241  VIVQLHKLRH LDISRDRLSS YYKFKLTREV LSLFVQKLGN LMSLDISGHM ILENCSISKM
   301  EEEAGQTSIE PSKSSIIPFR ALKRPLQFLG LFENSLCRLT HIPAYKVSGD KNEEQVLNAI
   361  EAYTEHRPEI TSRAINLLFD IARIERCNQL LRALKLVITA LKCHKYDRNI QVTGSAALFY
   421  LTNSEYRSEQ SVKLRRQVIQ VVLNGMESYQ EVTVQRNCCL TLCNFSIPEE LEFQYRRVNE
   481  LLLSILNPTR QDESIQRIAV HLCNALVCQV DNDHKEAVGK MGFVVTMLKL IQKKLLDKTC
   541  DQVMEFSWSA LWNITDETPD NCEMFLNFNG MKLFLDCLKE FPEKQELHRN MLGLLGNVAE
   601  VKELRPQLMT SQFISVFSNL LESKADGIEV SYNACGVLSH IMFDGPEAWG VCEPQREEVE
   661  ERMWAAIQSW DINSRRNINY RSFEPILRLL PQGISPVSQH WATWALYNLV SVYPDKYCPL
   721  LIKEGGMPLL RDIIKMATAR QETKEMARKV IEHCSNFKEE NMDTSR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZER1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.23
Highest tissue expression: 69 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 69 nTPM
skeletal muscle: 67 nTPM
amygdala: 51 nTPM
basal ganglia: 50 nTPM
hippocampal formation: 48 nTPM
hypothalamus: 47 nTPM

Single-cell type

neutrophils: 133 nCPM
myonuclei: 120 nCPM
proximal tubule cells: 119 nCPM
somatotrophs: 116 nCPM
retinal horizontal cells: 114 nCPM
distal convoluted tubule cells: 110 nCPM

Immune cell

neutrophil: 14 nTPM
basophil: 12 nTPM
eosinophil: 8.8 nTPM
MAIT T-cell: 6 nTPM
memory CD8 T-cell: 5.7 nTPM
non-classical monocyte: 5.2 nTPM

Brain region

cerebral cortex: 142 nTPM
basal ganglia: 128 nTPM
hippocampal formation: 121 nTPM
amygdala: 115 nTPM
hypothalamus: 111 nTPM
white matter: 104 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.18
gnomAD pLI: 1
gnomAD missense Z: 3.75
DepMap mean gene effect: -0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Cul2-RING ubiquitin ligase complex

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZER1 as an antibody target. Whether an autoantibody or antibody against ZER1 could matter depends on whether native ZER1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZER1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZER1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...