Seroatlas · Human Serome Atlas

ZDHHC8

Palmitoyltransferase ZDHHC8

Also known as: DHHC8, KIAA1292, ZDHC8_HUMAN, ZNF378

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9ULC8
Gene
ZDHHC8
Ensembl
ENSG00000099904
Chromosome
22
Canonical length
765 aa
Protein class
Enzymes, Metabolic proteins, Predicted membrane proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene encodes a four transmembrane protein that is a member of the zinc finger DHHC domain-containing protein family. The encoded protein may function as a palmitoyltransferase. Defects in this gene may be associated with a susceptibility to schizophrenia. Alternate splicing of this gene results in multiple transcript variants. A pseudogene of this gene is found on chromosome 22.[provided by RefSeq, May 2010]

Canonical amino-acid sequenceUniProt

765 residues, UniProt reviewed canonical sequence.

>Q9ULC8|ZDHHC8
     1  MPRSPGTRLK PAKYIPVATA AALLVGSSTL FFVFTCPWLT RAVSPAVPVY NGIIFLFVLA
    61  NFSMATFMDP GVFPRADEDE DKEDDFRAPL YKNVDVRGIQ VRMKWCATCH FYRPPRCSHC
   121  SVCDNCVEDF DHHCPWVNNC IGRRNYRYFF LFLLSLSAHM VGVVAFGLVY VLNHAEGLGA
   181  AHTTITMAVM CVAGLFFIPV IGLTGFHVVL VTRGRTTNEQ VTGKFRGGVN PFTRGCCGNV
   241  EHVLCSPLAP RYVVEPPRLP LAVSLKPPFL RPELLDRAAP LKVKLSDNGL KAGLGRSKSK
   301  GSLDRLDEKP LDLGPPLPPK IEAGTFSSDL QTPRPGSAES ALSVQRTSPP TPAMYKFRPA
   361  FPTGPKVPFC GPGEQVPGPD SLTLGDDSIR SLDFVSEPSL DLPDYGPGGL HAAYPPSPPL
   421  SASDAFSGAL RSLSLKASSR RGGDHVALQP LRSEGGPPTP HRSIFAPHAL PNRNGSLSYD
   481  SLLNPGSPGG HACPAHPAVG VAGYHSPYLH PGATGDPPRP LPRSFSPVLG PRPREPSPVR
   541  YDNLSRTIMA SIQERKDREE RERLLRSQAD SLFGDSGVYD APSSYSLQQA SVLSEGPRGP
   601  ALRYGSRDDL VAGPGFGGAR NPALQTSLSS LSSSVSRAPR TSSSSLQADQ ASSNAPGPRP
   661  SSGSHRSPAR QGLPSPPGTP HSPSYAGPKA VAFIHTDLPE PPPSLTVQRD HPQLKTPPSK
   721  LNGQSPGLAR LGPATGPPGP SASPTRHTLV KKVSGVGGTT YEISV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZDHHC8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
4
Mean surface accessibility (rSASA)
0.58
Highest tissue expression
44 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 44 nTPM
  • pituitary gland: 38 nTPM
  • thyroid gland: 36 nTPM
  • cerebral cortex: 35 nTPM
  • kidney: 34 nTPM
  • liver: 34 nTPM

Single-cell type

  • epididymal principal cells: 57 nCPM
  • retinal amacrine cells: 28 nCPM
  • retinal horizontal cells: 26 nCPM
  • alveolar cells type 1: 24 nCPM
  • astrocytes: 23 nCPM
  • bergmann glia: 23 nCPM

Immune cell

  • basophil: 1.3 nTPM
  • plasmacytoid DC: 1.3 nTPM
  • gdT-cell: 0.8 nTPM
  • T-reg: 0.7 nTPM
  • intermediate monocyte: 0.5 nTPM
  • naive B-cell: 0.5 nTPM

Brain region

  • cerebral cortex: 69 nTPM
  • hippocampal formation: 56 nTPM
  • amygdala: 55 nTPM
  • basal ganglia: 55 nTPM
  • medulla oblongata: 53 nTPM
  • white matter: 53 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.37
gnomAD pLI
0.85
gnomAD missense Z
1.85
DepMap mean gene effect
-0.22
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZDHHC8 as an antibody target. Whether an autoantibody or antibody against ZDHHC8 could matter depends on whether native ZDHHC8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZDHHC8 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZDHHC8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZDHHC8. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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