ZDHHC7
Palmitoyltransferase ZDHHC7
Also known as: DHHC7, FLJ10792, FLJ20279, SERZ-B, SERZ1, ZDHC7_HUMAN, ZNF370
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9NXF8
- Gene
- ZDHHC7
- Ensembl
- ENSG00000153786
- Chromosome
- 16
- Canonical length
- 308 aa
- Protein class
- Enzymes, Metabolic proteins, Predicted membrane proteins
- Subcellular location
- Golgi apparatus
- Quaternary structure
- Homooligomer
OverviewNCBI Gene
Enables protein-cysteine S-palmitoyltransferase activity. Involved in several processes, including nuclear receptor-mediated steroid hormone signaling pathway; regulation of protein localization; and regulation of signal transduction. Located in Golgi apparatus and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
308 residues, UniProt reviewed canonical sequence.
>Q9NXF8|ZDHHC7
1 MQPSGHRLRD VEHHPLLAEN DNYDSSSSSS SEADVADRVW FIRDGCGMIC AVMTWLLVAY
61 ADFVVTFVML LPSKDFWYSV VNGVIFNCLA VLALSSHLRT MLTDPGAVPK GNATKEYMES
121 LQLKPGEVIY KCPKCCCIKP ERAHHCSICK RCIRKMDHHC PWVNNCVGEK NQRFFVLFTM
181 YIALSSVHAL ILCGFQFISC VRGQWTECSD FSPPITVILL IFLCLEGLLF FTFTAVMFGT
241 QIHSICNDET EIERLKSEKP TWERRLRWEG MKSVFGGPPS LLWMNPFVGF RFRRLPTRPR
301 KGGPEFSVLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ZDHHC7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 4
- Mean surface accessibility (rSASA)
- 0.36
- Highest tissue expression
- 61 nTPM
Expression across tissuesHPA
Tissue
- bone marrow: 61 nTPM
- tongue: 55 nTPM
- skeletal muscle: 53 nTPM
- stomach: 42 nTPM
- colon: 40 nTPM
- urinary bladder: 35 nTPM
Single-cell type
- alveolar cells type 1: 125 nCPM
- neutrophils: 98 nCPM
- endometrial glandular cells: 90 nCPM
- monocytes: 89 nCPM
- kupffer cells: 76 nCPM
- conjunctival goblet cells: 75 nCPM
Immune cell
- classical monocyte: 9.7 nTPM
- eosinophil: 8.3 nTPM
- intermediate monocyte: 8.2 nTPM
- basophil: 7.5 nTPM
- non-classical monocyte: 7.2 nTPM
- neutrophil: 6.4 nTPM
Brain region
- choroid plexus: 50 nTPM
- thalamus: 44 nTPM
- midbrain: 38 nTPM
- cerebellum: 37 nTPM
- pons: 36 nTPM
- medulla oblongata: 36 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.79
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.6
- DepMap mean gene effect
- -0.09
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- androgen receptor signaling pathway
- glucose import in response to insulin stimulus
- peptidyl-L-cysteine S-palmitoylation
- polarized epithelial cell differentiation
- positive regulation of D-glucose transmembrane transport
- progesterone receptor signaling pathway
- protein localization to plasma membrane
- protein palmitoylation
- protein targeting to membrane
- regulation of Fas signaling pathway
- regulation of G protein-coupled receptor signaling pathway
- regulation of protein localization to plasma membrane
- steroid hormone receptor signaling pathway
- negative regulation of catabolic process
- regulation of protein localization to cell-cell junction
Molecular functions
- palmitoyltransferase activity
- protein-cysteine S-myristoyltransferase activity
- protein-cysteine S-palmitoyltransferase activity
- protein-cysteine S-stearoyltransferase activity
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ZDHHC7 as an antibody target. Whether an autoantibody or antibody against ZDHHC7 could matter depends on whether native ZDHHC7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ZDHHC7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ZDHHC7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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