Seroatlas · Human Serome Atlas

ZDHHC4

Palmitoyltransferase ZDHHC4

Also known as: FLJ10479, ZDHC4_HUMAN, ZNF374

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NPG8
Gene: ZDHHC4
Ensembl: ENSG00000136247
Chromosome: 7
Canonical length: 344 aa
Protein class: Enzymes, Metabolic proteins, Predicted membrane proteins

OverviewNCBI Gene

Enables palmitoyltransferase activity. Involved in positive regulation of innate immune response and protein localization to plasma membrane. Located in Golgi apparatus and endoplasmic reticulum. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

344 residues, UniProt reviewed canonical sequence.

>Q9NPG8|ZDHHC4
     1  MDFLVLFLFY LASVLMGLVL ICVCSKTHSL KGLARGGAQI FSCIIPECLQ RAVHGLLHYL
    61  FHTRNHTFIV LHLVLQGMVY TEYTWEVFGY CQELELSLHY LLLPYLLLGV NLFFFTLTCG
   121  TNPGIITKAN ELLFLHVYEF DEVMFPKNVR CSTCDLRKPA RSKHCSVCNW CVHRFDHHCV
   181  WVNNCIGAWN IRYFLIYVLT LTASAATVAI VSTTFLVHLV VMSDLYQETY IDDLGHLHVM
   241  DTVFLIQYLF LTFPRIVFML GFVVVLSFLL GGYLLFVLYL AATNQTTNEW YRGDWAWCQR
   301  CPLVAWPPSA EPQVHRNIHS HGLRSNLQEI FLPAFPCHER KKQE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZDHHC4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 5
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 44 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 44 nTPM
tongue: 41 nTPM
choroid plexus: 35 nTPM
thyroid gland: 34 nTPM
testis: 34 nTPM
liver: 33 nTPM

Single-cell type

early primary spermatocytes: 104 nCPM
extravillous trophoblasts: 88 nCPM
migrating cytotrophoblasts: 84 nCPM
cytotrophoblasts: 80 nCPM
decidual stromal cells: 78 nCPM
epididymal principal cells: 68 nCPM

Immune cell

plasmacytoid DC: 114 nTPM
basophil: 56 nTPM
eosinophil: 45 nTPM
memory B-cell: 39 nTPM
naive B-cell: 36 nTPM
intermediate monocyte: 32 nTPM

Brain region

midbrain: 23 nTPM
choroid plexus: 22 nTPM
hypothalamus: 22 nTPM
pons: 21 nTPM
medulla oblongata: 20 nTPM
white matter: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.53
gnomAD pLI: 0
gnomAD missense Z: -0.06
DepMap mean gene effect: -0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZDHHC4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

CPT1A

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZDHHC4 as an antibody target. Whether an autoantibody or antibody against ZDHHC4 could matter depends on whether native ZDHHC4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZDHHC4 is annotated at the cell surface, where native ZDHHC4 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ZDHHC4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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