Seroatlas · Human Serome Atlas

ZDHHC24

Probable palmitoyltransferase ZDHHC24

Also known as: ZDH24_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6UX98
Gene: ZDHHC24
Ensembl: ENSG00000174165
Chromosome: 11
Canonical length: 284 aa
Protein class: Enzymes, Metabolic proteins, Predicted membrane proteins
Subcellular location: Vesicles,Cytosol

OverviewNCBI Gene

Predicted to enable protein-cysteine S-palmitoyltransferase activity. Predicted to be involved in protein targeting to membrane. Predicted to be located in membrane. Predicted to be active in Golgi apparatus and endoplasmic reticulum. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

284 residues, UniProt reviewed canonical sequence.

>Q6UX98|ZDHHC24
     1  MGQPWAAGST DGAPAQLPLV LTALWAAAVG LELAYVLVLG PGPPPLGPLA RALQLALAAF
    61  QLLNLLGNVG LFLRSDPSIR GVMLAGRGLG QGWAYCYQCQ SQVPPRSGHC SACRVCILRR
   121  DHHCRLLGRC VGFGNYRPFL CLLLHAAGVL LHVSVLLGPA LSALLRAHTP LHMAALLLLP
   181  WLMLLTGRVS LAQFALAFVT DTCVAGALLC GAGLLFHGML LLRGQTTWEW ARGQHSYDLG
   241  PCHNLQAALG PRWALVWLWP FLASPLPGDG ITFQTTADVG HTAS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZDHHC24 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 5
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 7.5 nTPM

Expression across tissuesHPA

Tissue

spleen: 7.5 nTPM
pancreas: 7.3 nTPM
adrenal gland: 6.9 nTPM
basal ganglia: 6.4 nTPM
kidney: 6.4 nTPM
thyroid gland: 6.3 nTPM

Single-cell type

epididymal principal cells: 79 nCPM
esophageal suprabasal cells: 72 nCPM
hofbauer cells: 68 nCPM
enterocytes: 52 nCPM
epicardial cells: 52 nCPM
kupffer cells: 52 nCPM

Immune cell

plasmacytoid DC: 23 nTPM
memory CD8 T-cell: 8.4 nTPM
NK-cell: 7.9 nTPM
naive B-cell: 7.5 nTPM
gdT-cell: 7.3 nTPM
myeloid DC: 7.1 nTPM

Brain region

hypothalamus: 21 nTPM
amygdala: 20 nTPM
choroid plexus: 20 nTPM
medulla oblongata: 19 nTPM
cerebral cortex: 19 nTPM
midbrain: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.41
gnomAD pLI: 0
gnomAD missense Z: 0.29
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

protein targeting to membrane

Molecular functions

protein-cysteine S-palmitoyltransferase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZDHHC24 as an antibody target. Whether an autoantibody or antibody against ZDHHC24 could matter depends on whether native ZDHHC24 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZDHHC24 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZDHHC24 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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