ZDHHC21
Palmitoyltransferase ZDHHC21
Also known as: DHHC21, DNZ1, HSPC097, ZDH21_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8IVQ6
- Gene
- ZDHHC21
- Ensembl
- ENSG00000175893
- Chromosome
- 9
- Canonical length
- 265 aa
- Protein class
- Enzymes, Metabolic proteins, Predicted membrane proteins
- Subcellular location
- Golgi apparatus,Cytosol
OverviewNCBI Gene
Enables protein-cysteine S-palmitoyltransferase activity. Involved in peptidyl-L-cysteine S-palmitoylation. Located in Golgi apparatus and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
265 residues, UniProt reviewed canonical sequence.
>Q8IVQ6|ZDHHC21
1 MGLRIHFVVD PHGWCCMGLI VFVWLYNIVL IPKIVLFPHY EEGHIPGILI IIFYGISIFC
61 LVALVRASIT DPGRLPENPK IPHGEREFWE LCNKCNLMRP KRSHHCSRCG HCVRRMDHHC
121 PWINNCVGED NHWLFLQLCF YTELLTCYAL MFSFCHYYYF LPLKKRNLDL FVFRHELAIM
181 RLAAFMGITM LVGITGLFYT QLIGIITDTT SIEKMSNCCE DISRPRKPWQ QTFSEVFGTR
241 WKILWFIPFR QRQPLRVPYH FANHVLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ZDHHC21 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 4
- Mean surface accessibility (rSASA)
- 0.31
- Highest tissue expression
- 9.9 nTPM
Expression across tissuesHPA
Tissue
- cerebellum: 9.9 nTPM
- retina: 9.8 nTPM
- cerebral cortex: 9 nTPM
- skin: 8.2 nTPM
- esophagus: 8 nTPM
- small intestine: 6.8 nTPM
Single-cell type
- bergmann glia: 366 nCPM
- lactotrophs: 318 nCPM
- oligodendrocyte progenitor cells: 297 nCPM
- thyrotrophs: 279 nCPM
- pituicytes/fscs: 269 nCPM
- choroid plexus epithelial cells: 256 nCPM
Immune cell
- memory B-cell: 2 nTPM
- naive B-cell: 1.4 nTPM
- NK-cell: 1.1 nTPM
- T-reg: 0.6 nTPM
- plasmacytoid DC: 0.5 nTPM
- gdT-cell: 0.4 nTPM
Brain region
- cerebellum: 36 nTPM
- cerebral cortex: 24 nTPM
- basal ganglia: 20 nTPM
- white matter: 20 nTPM
- hypothalamus: 19 nTPM
- pons: 18 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.74
- gnomAD pLI
- 0.03
- gnomAD missense Z
- 0.32
- DepMap mean gene effect
- 0.08
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- adrenergic receptor signaling pathway
- hair follicle development
- nitric oxide metabolic process
- peptidyl-L-cysteine S-palmitoylation
- protein targeting to membrane
- regulation of establishment of endothelial barrier
- regulation of vascular associated smooth muscle contraction
- sebaceous gland development
- regulation of leukocyte adhesion to arterial endothelial cell
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ZDHHC21 as an antibody target. Whether an autoantibody or antibody against ZDHHC21 could matter depends on whether native ZDHHC21 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ZDHHC21 is annotated at the cell surface, where native ZDHHC21 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label ZDHHC21 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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