Seroatlas · Human Serome Atlas

ZDHHC20

Palmitoyltransferase ZDHHC20

Also known as: DHHC20, FLJ25952, ZDH20_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5W0Z9
Gene: ZDHHC20
Ensembl: ENSG00000180776
Chromosome: 13
Canonical length: 365 aa
Protein class: Enzymes, Metabolic proteins, Predicted membrane proteins, Transporters
Subcellular location: Vesicles,Plasma membrane

OverviewNCBI Gene

Enables protein-cysteine S-palmitoyltransferase activity and zinc ion binding activity. Involved in peptidyl-L-cysteine S-palmitoylation and positive regulation by host of viral process. Located in Golgi membrane and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

365 residues, UniProt reviewed canonical sequence.

>Q5W0Z9|ZDHHC20
     1  MAPWTLWRCC QRVVGWVPVL FITFVVVWSY YAYVVELCVF TIFGNEENGK TVVYLVAFHL
    61  FFVMFVWSYW MTIFTSPASP SKEFYLSNSE KERYEKEFSQ ERQQEILRRA ARALPIYTTS
   121  ASKTIRYCEK CQLIKPDRAH HCSACDSCIL KMDHHCPWVN NCVGFSNYKF FLLFLLYSLL
   181  YCLFVAATVL EYFIKFWTNE LTDTRAKFHV LFLFFVSAMF FISVLSLFSY HCWLVGKNRT
   241  TIESFRAPTF SYGPDGNGFS LGCSKNWRQV FGDEKKYWLL PIFSSLGDGC SFPTRLVGMD
   301  PEQASVTNQN EYARSSGSNQ PFPIKPLSES KNRLLDSESQ WLENGAEEGI VKSGTNNHVT
   361  VAIEN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZDHHC20 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 37 nTPM

Expression across tissuesHPA

Tissue

stomach: 37 nTPM
spinal cord: 31 nTPM
esophagus: 28 nTPM
bone marrow: 27 nTPM
testis: 27 nTPM
urinary bladder: 21 nTPM

Single-cell type

neutrophils: 1,413 nCPM
monocytes: 564 nCPM
oligodendrocytes: 445 nCPM
esophageal apical cells: 443 nCPM
neutrophil progenitors: 378 nCPM
foveolar cells: 326 nCPM

Immune cell

classical monocyte: 16 nTPM
intermediate monocyte: 15 nTPM
non-classical monocyte: 14 nTPM
total PBMC: 14 nTPM
basophil: 13 nTPM
NK-cell: 11 nTPM

Brain region

white matter: 211 nTPM
medulla oblongata: 169 nTPM
pons: 138 nTPM
cerebellum: 130 nTPM
basal ganglia: 129 nTPM
thalamus: 107 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.75
gnomAD pLI: 0
gnomAD missense Z: 1.25
DepMap mean gene effect: -0.16
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZDHHC20 as an antibody target. Whether an autoantibody or antibody against ZDHHC20 could matter depends on whether native ZDHHC20 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZDHHC20 is annotated at the cell surface, where native ZDHHC20 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ZDHHC20 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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