Seroatlas · Human Serome Atlas

ZDHHC2

Palmitoyltransferase ZDHHC2

Also known as: DHHC2, ZDHC2_HUMAN, ZNF372

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UIJ5
Gene: ZDHHC2
Ensembl: ENSG00000104219
Chromosome: 8
Canonical length: 367 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Plasma membrane
Quaternary structure: Homodimer

OverviewNCBI Gene

Enables protein homodimerization activity and protein-cysteine S-palmitoyltransferase activity. Involved in several processes, including peptidyl-L-cysteine S-palmitoylation; protein localization to membrane raft; and synapse assembly. Located in Golgi apparatus; endoplasmic reticulum membrane; and plasma membrane. Is active in postsynaptic recycling endosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

367 residues, UniProt reviewed canonical sequence.

>Q9UIJ5|ZDHHC2
     1  MAPSGPGSSA RRRCRRVLYW IPVVFITLLL GWSYYAYAIQ LCIVSMENTG EQVVCLMAYH
    61  LLFAMFVWSY WKTIFTLPMN PSKEFHLSYA EKDLLEREPR GEAHQEVLRR AAKDLPIYTR
   121  TMSGAIRYCD RCQLIKPDRC HHCSVCDKCI LKMDHHCPWV NNCVGFSNYK FFLLFLAYSL
   181  LYCLFIAATD LQYFIKFWTN GLPDTQAKFH IMFLFFAAAM FSVSLSSLFG YHCWLVSKNK
   241  STLEAFRSPV FRHGTDKNGF SLGFSKNMRQ VFGDEKKYWL LPIFSSLGDG CSFPTCLVNQ
   301  DPEQASTPAG LNSTAKNLEN HQFPAKPLRE SQSHLLTDSQ SWTESSINPG KCKAGMSNPA
   361  LTMENET

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZDHHC2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 72 nTPM

Expression across tissuesHPA

Tissue

retina: 72 nTPM
tongue: 35 nTPM
thyroid gland: 31 nTPM
bone marrow: 30 nTPM
pancreas: 29 nTPM
parathyroid gland: 27 nTPM

Single-cell type

rod photoreceptor cells: 337 nCPM
cone photoreceptor cells: 236 nCPM
retinal bipolar cells: 197 nCPM
megakaryocyte-erythroid progenitors: 189 nCPM
sertoli cells: 156 nCPM
neutrophil progenitors: 145 nCPM

Immune cell

MAIT T-cell: 3.3 nTPM
eosinophil: 2.6 nTPM
memory B-cell: 2.5 nTPM
memory CD4 T-cell: 2.4 nTPM
memory CD8 T-cell: 2.3 nTPM
naive CD8 T-cell: 2.3 nTPM

Brain region

cerebellum: 115 nTPM
hypothalamus: 77 nTPM
white matter: 69 nTPM
medulla oblongata: 61 nTPM
pons: 57 nTPM
midbrain: 52 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.69
gnomAD pLI: 0
gnomAD missense Z: -0.3
DepMap mean gene effect: -0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZDHHC2 as an antibody target. Whether an autoantibody or antibody against ZDHHC2 could matter depends on whether native ZDHHC2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZDHHC2 is annotated at the cell surface, where native ZDHHC2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ZDHHC2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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