Seroatlas · Human Serome Atlas

ZDHHC18

Palmitoyltransferase ZDHHC18

Also known as: DKFZp667O2416, ZDH18_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NUE0
Gene: ZDHHC18
Ensembl: ENSG00000204160
Chromosome: 1
Canonical length: 388 aa
Protein class: Enzymes, Metabolic proteins, Predicted membrane proteins
Subcellular location: Golgi apparatus,Cytosol

OverviewNCBI Gene

Enables protein-cysteine S-palmitoyltransferase activity. Involved in negative regulation of cGAS/STING signaling pathway; negative regulation of innate immune response; and peptidyl-L-cysteine S-palmitoylation. Located in cytosol. Is active in Golgi apparatus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

388 residues, UniProt reviewed canonical sequence.

>Q9NUE0|ZDHHC18
     1  MKDCEYQQIS PGAAPLPASP GARRPGPAAS PTPGPGPAPP AAPAPPRWSS SGSGSGSGSG
    61  SLGRRPRRKW EVFPGRNRFY CGGRLMLAGH GGVFALTLLL ILTTTGLFFV FDCPYLARKL
   121  TLAIPIIAAI LFFFVMSCLL QTSFTDPGIL PRATVCEAAA LEKQIDNTGS STYRPPPRTR
   181  EVLINGQMVK LKYCFTCKMF RPPRTSHCSV CDNCVERFDH HCPWVGNCVG RRNYRFFYAF
   241  ILSLSFLTAF IFACVVTHLT LRAQGSNFLS TLKETPASVL ELVICFFSIW SILGLSGFHT
   301  YLVASNLTTN EDIKGSWSSK RGGEASVNPY SHKSIITNCC AVLCGPLPPS LIDRRGFVQS
   361  DTVLPSPIRS DEPACRAKPD ASMVGGHP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZDHHC18 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 108 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 108 nTPM
spleen: 29 nTPM
appendix: 26 nTPM
esophagus: 23 nTPM
cerebellum: 23 nTPM
adipose tissue: 22 nTPM

Single-cell type

neutrophils: 582 nCPM
neutrophil progenitors: 74 nCPM
suprabasal keratinocytes: 54 nCPM
esophageal apical cells: 49 nCPM
esophageal suprabasal cells: 40 nCPM
rod photoreceptor cells: 40 nCPM

Immune cell

neutrophil: 49 nTPM
eosinophil: 10 nTPM
T-reg: 2.7 nTPM
gdT-cell: 1.6 nTPM
memory CD4 T-cell: 1.2 nTPM
memory CD8 T-cell: 1.2 nTPM

Brain region

pons: 52 nTPM
hypothalamus: 43 nTPM
cerebral cortex: 41 nTPM
midbrain: 41 nTPM
medulla oblongata: 40 nTPM
thalamus: 36 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.81
gnomAD pLI: 0
gnomAD missense Z: 1.66
DepMap mean gene effect: -0.19
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZDHHC18 as an antibody target. Whether an autoantibody or antibody against ZDHHC18 could matter depends on whether native ZDHHC18 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZDHHC18 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZDHHC18 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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