Seroatlas · Human Serome Atlas

ZDHHC15

Palmitoyltransferase ZDHHC15

Also known as: DHHC15, FLJ31812, MRX91, ZDH15_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96MV8
Gene
ZDHHC15
Ensembl
ENSG00000102383
Chromosome
X
Canonical length
337 aa
Protein class
Disease related genes, Enzymes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted membrane proteins
Subcellular location
Nuclear speckles,Cytosol

OverviewNCBI Gene

The protein encoded by this gene belongs to the DHHC palmitoyltransferase family. Mutations in this gene are associated with mental retardatio X-linked type 91 (MRX91). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

Canonical amino-acid sequenceUniProt

337 residues, UniProt reviewed canonical sequence.

>Q96MV8|ZDHHC15
     1  MRRGWKMALS GGLRCCRRVL SWVPVLVIVL VVLWSYYAYV FELCLVTVLS PAEKVIYLIL
    61  YHAIFVFFTW TYWKSIFTLP QQPNQKFHLS YTDKERYENE ERPEVQKQML VDMAKKLPVY
   121  TRTGSGAVRF CDRCHLIKPD RCHHCSVCAM CVLKMDHHCP WVNNCIGFSN YKFFLQFLAY
   181  SVLYCLYIAT TVFSYFIKYW RGELPSVRSK FHVLFLLFVA CMFFVSLVIL FGYHCWLVSR
   241  NKTTLEAFCT PVFTSGPEKN GFNLGFIKNI QQVFGDKKKF WLIPIGSSPG DGHSFPMRSM
   301  NESQNPLLAN EETWEDNEDD NQDYPEGSSS LAVETET

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZDHHC15 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
4
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
4.2 nTPM

Expression across tissuesHPA

Tissue

  • salivary gland: 4.2 nTPM
  • cerebral cortex: 2.7 nTPM
  • ovary: 2.2 nTPM
  • hypothalamus: 2 nTPM
  • endometrium: 1.8 nTPM
  • retina: 1.8 nTPM

Single-cell type

  • cardiomyocytes: 86 nCPM
  • epicardial cells: 71 nCPM
  • lactotrophs: 41 nCPM
  • thyrotrophs: 39 nCPM
  • oligodendrocyte progenitor cells: 36 nCPM
  • choroid plexus epithelial cells: 35 nCPM

Immune cell

  • naive CD4 T-cell: 0.1 nTPM
  • naive CD8 T-cell: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM

Brain region

  • hypothalamus: 7.3 nTPM
  • medulla oblongata: 6 nTPM
  • midbrain: 5.7 nTPM
  • white matter: 5.3 nTPM
  • pons: 5.1 nTPM
  • spinal cord: 5.1 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ZDHHC15.

Disease | AllUniProt

Conditions ZDHHC15 is implicated in, by any mechanism.

  • Intellectual developmental disorder, X-linked 91 (MRX91) MIM:300577

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 122 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Spastic diplegia

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.43
gnomAD pLI
0.84
gnomAD missense Z
1.03
DepMap mean gene effect
0.02
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZDHHC15 as an antibody target. Whether an autoantibody or antibody against ZDHHC15 could matter depends on whether native ZDHHC15 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZDHHC15 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZDHHC15 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZDHHC15. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...