Seroatlas · Human Serome Atlas

ZDHHC14

Palmitoyltransferase ZDHHC14

Also known as: FLJ20984, NEW1CP, ZDH14_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IZN3
Gene: ZDHHC14
Ensembl: ENSG00000175048
Chromosome: 6
Canonical length: 488 aa
Protein class: Enzymes, Metabolic proteins, Predicted membrane proteins
Subcellular location: Vesicles

OverviewNCBI Gene

Enables palmitoyltransferase activity. Involved in peptidyl-L-cysteine S-palmitoylation. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

488 residues, UniProt reviewed canonical sequence.

>Q8IZN3|ZDHHC14
     1  MPPGGGGPMK DCEYSQISTH SSSPMESPHK KKKIAARRKW EVFPGRNKFF CNGRIMMARQ
    61  TGVFYLTLVL ILVTSGLFFA FDCPYLAVKI TPAIPAVAGI LFFFVMGTLL RTSFSDPGVL
   121  PRATPDEAAD LERQIDIANG TSSGGYRPPP RTKEVIINGQ TVKLKYCFTC KIFRPPRASH
   181  CSLCDNCVER FDHHCPWVGN CVGKRNYRFF YMFILSLSFL TVFIFAFVIT HVILRSQQTG
   241  FLNALKDSPA SVLEAVVCFF SVWSIVGLSG FHTYLISSNQ TTNEDIKGSW SNKRGKENYN
   301  PYSYGNIFTN CCVALCGPIS PSLIDRRGYI QPDTPQPAAP SNGITMYGAT QSQSDMCDQD
   361  QCIQSTKFVL QAAATPLLQS EPSLTSDELH LPGKPGLGTP CASLTLGPPT PPASMPNLAE
   421  ATLADVMPRK DEHMGHQFLT PDEAPSPPRL LAAGSPLAHS RTMHVLGLAS QDSLHEDSVR
   481  GLVKLSSV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZDHHC14 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 11 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 11 nTPM
endometrium: 9.7 nTPM
cerebral cortex: 6.3 nTPM
smooth muscle: 5.7 nTPM
cerebellum: 5.6 nTPM
parathyroid gland: 5.3 nTPM

Single-cell type

bergmann glia: 604 nCPM
oligodendrocyte progenitor cells: 579 nCPM
distal convoluted tubule cells: 574 nCPM
lymphatic endothelial cells: 473 nCPM
erythrocyte progenitors: 404 nCPM
ependymal cells: 397 nCPM

Immune cell

plasmacytoid DC: 1.3 nTPM
memory B-cell: 0.4 nTPM
MAIT T-cell: 0.2 nTPM
naive B-cell: 0.2 nTPM
gdT-cell: 0.1 nTPM
memory CD4 T-cell: 0.1 nTPM

Brain region

white matter: 56 nTPM
spinal cord: 37 nTPM
medulla oblongata: 35 nTPM
thalamus: 31 nTPM
cerebellum: 29 nTPM
pons: 29 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.42
gnomAD pLI: 0.72
gnomAD missense Z: 2.24
DepMap mean gene effect: 0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZDHHC14 as an antibody target. Whether an autoantibody or antibody against ZDHHC14 could matter depends on whether native ZDHHC14 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZDHHC14 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZDHHC14 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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