Seroatlas · Human Serome Atlas

ZDHHC11B

Probable palmitoyltransferase ZDHHC11B

Also known as: ZH11B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0C7U3
Gene: ZDHHC11B
Ensembl: ENSG00000206077
Chromosome: 5
Canonical length: 371 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Golgi apparatus

OverviewNCBI Gene

Predicted to enable protein-cysteine S-palmitoyltransferase activity. Predicted to be involved in several processes, including antiviral innate immune response; peptidyl-L-cysteine S-palmitoylation; and positive regulation of defense response to virus by host. Predicted to be located in endosome membrane. Predicted to be active in Golgi apparatus and endoplasmic reticulum. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

371 residues, UniProt reviewed canonical sequence.

>P0C7U3|ZDHHC11B
     1  MDTRSGSQCS VTPEAIRNNE ELVLPPRISR VNGWSLPLHY FRVVTWAVFV GLSLATFRIF
    61  IPLLPHSWKY IAYVVTGGIF SFHLVVHLIA SCIDPADSNV RLMKNYSQPM PLFDRSKHAH
   121  VIQNQFCHLC KVTVNKKTKH CISCNKCVSG FDHHCKWINN CVGSRNYWFF FSTVASATAG
   181  MLCLIAILLY VLVQYLVNPR VLRTDPRYED VKNMNTWLLF LPLFPVQVQT LIVVIIRMLV
   241  LLLDLLGLVQ LGQLLIFHIY LKAKKMTTFE YLINTRKEES SKHQAVRKDP YVQMDKGFLQ
   301  QGAGALGSSA QGVKAKSSLL IYKCPCHFCT SVNQDGDSKA QEADDAPSTS TLGLQQETTE
   361  PMKTDSAESE D

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZDHHC11B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 5
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 36 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 36 nTPM
hippocampal formation: 20 nTPM
basal ganglia: 18 nTPM
cerebral cortex: 17 nTPM
pituitary gland: 16 nTPM
amygdala: 15 nTPM

Single-cell type

thyrotrophs: 224 nCPM
somatotrophs: 147 nCPM
lactotrophs: 127 nCPM
cardiomyocytes: 87 nCPM
oligodendrocytes: 82 nCPM
corticotrophs: 82 nCPM

Immune cell

gdT-cell: 0.1 nTPM
memory CD4 T-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

white matter: 81 nTPM
cerebral cortex: 66 nTPM
basal ganglia: 54 nTPM
thalamus: 53 nTPM
pons: 51 nTPM
medulla oblongata: 51 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.64
gnomAD pLI: 0
gnomAD missense Z: -0.81

OntologyGO

Biological processes

Molecular functions

protein-cysteine S-palmitoyltransferase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZDHHC11B as an antibody target. Whether an autoantibody or antibody against ZDHHC11B could matter depends on whether native ZDHHC11B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZDHHC11B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZDHHC11B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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