Seroatlas · Human Serome Atlas

ZCWPW2

Zinc finger CW-type PWWP domain protein 2

Also known as: ZCPW2_HUMAN, ZCW2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q504Y3
Gene: ZCWPW2
Ensembl: ENSG00000206559
Chromosome: 3
Canonical length: 356 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nuclear speckles

OverviewNCBI Gene

Enables methylated histone binding activity. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

356 residues, UniProt reviewed canonical sequence.

>Q504Y3|ZCWPW2
     1  MDKEKLDVKI EYCNYAMDSS VENMYVNKVW VQCENENCLK WRLLSSEDSA KVDHDEPWYC
    61  FMNTDSRYNN CSISEEDFPE ESQLHQCGFK IVYSQLPLGS LVLVKLQNWP SWPGILCPDR
   121  FKGKYVTYDP DGNVEEYHIE FLGDPHSRSW IKATFVGHYS ITLKPEKCKN KKKWYKSALQ
   181  EACLLYGYSH EQRLEMCCLS KLQDKSETHD KVAALVKKRK QTSKNNIEKK KPKFRKRKRK
   241  AILKCSFENV YSDDALSKEN RVVCETEVLL KELEQMLQQA LQPTATPDES EEGHGEEINM
   301  GEKLSKCSPE APAGSLFENH YEEDYLVIDG IKLKAGECIE DITNKFKEID ALMSEF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZCWPW2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 9.3 nTPM

Expression across tissuesHPA

Tissue

testis: 9.3 nTPM
skeletal muscle: 5.8 nTPM
tongue: 4.2 nTPM
heart muscle: 2.6 nTPM
thyroid gland: 2.4 nTPM
prostate: 2.1 nTPM

Single-cell type

late primary spermatocytes: 135 nCPM
epicardial cells: 80 nCPM
cardiomyocytes: 78 nCPM
astrocytes: 70 nCPM
choroid plexus epithelial cells: 60 nCPM
ependymal cells: 57 nCPM

Immune cell

basophil: 1.1 nTPM
eosinophil: 1.1 nTPM
neutrophil: 1.1 nTPM
classical monocyte: 0.7 nTPM
intermediate monocyte: 0.7 nTPM
naive CD8 T-cell: 0.7 nTPM

Brain region

cerebral cortex: 8.7 nTPM
amygdala: 8.5 nTPM
basal ganglia: 8.4 nTPM
cerebellum: 8.2 nTPM
hippocampal formation: 8 nTPM
white matter: 7.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.03
gnomAD pLI: 0
gnomAD missense Z: -0.91
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZCWPW2 as an antibody target. Whether an autoantibody or antibody against ZCWPW2 could matter depends on whether native ZCWPW2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZCWPW2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZCWPW2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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