Seroatlas · Human Serome Atlas

ZCWPW1

Zinc finger CW-type PWWP domain protein 1

Also known as: DKFZp434N0510, FLJ10057, ZCPW1_HUMAN, ZCW1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H0M4
Gene: ZCWPW1
Ensembl: ENSG00000078487
Chromosome: 7
Canonical length: 648 aa
Protein class: Predicted intracellular proteins
Subcellular location: Golgi apparatus

OverviewNCBI Gene

Enables histone reader activity; methyl-CpG binding activity; and methylated histone binding activity. Predicted to be involved in meiosis I; positive regulation of DNA metabolic process; and spermatogenesis. Predicted to act upstream of or within homologous chromosome pairing at meiosis. Predicted to be located in XY body. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

648 residues, UniProt reviewed canonical sequence.

>Q9H0M4|ZCWPW1
     1  MMTTLQNKEE CGKGPKRIFA PPAQKSYSLL PCSPNSPKEE TPGISSPETE ARISLPKASL
    61  KKKEEKATMK NVPSREQEKK RKAQINKQAE KKEKEKSSLT NAEFEEIVQI VLQKSLQECL
   121  GMGSGLDFAE TSCAQPVVST QSDKEPGITA SATDTDNANG EEVPHTQEIS VSWEGEAAPE
   181  IRTSKLGQPD PAPSKKKSNR LTLSKRKKEA HEKVEKTQGG HEHRQEDRLK KTVQDHSQIR
   241  DQQKGEISGF GQCLVWVQCS FPNCGKWRRL CGNIDPSVLP DNWSCDQNTD VQYNRCDIPE
   301  ETWTGLESDV AYASYIPGSI IWAKQYGYPW WPGMIESDPD LGEYFLFTSH LDSLPSKYHV
   361  TFFGETVSRA WIPVNMLKNF QELSLELSVM KKRRNDCSQK LGVALMMAQE AEQISIQERV
   421  NLFGFWSRFN GSNSNGERKD LQLSGLNSPG SCLEKKEKEE ELEKEEGEKT DPILPIRKRV
   481  KIQTQKTKPR GLGGDAGTAD GRGRTLQRKI MKRSLGRKST APPAPRMGRK EGQGNSDSDQ
   541  PGPKKKFKAP QSKALAASFS EGKEVRTVPK NLGLSACKGA CPSSAKEEPR HREPLTQEAG
   601  SVPLEDEASS DLDLEQLMED VGRELGQSGE LQHSNSDGED FPVALFGK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZCWPW1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.59
Highest tissue expression: 36 nTPM

Expression across tissuesHPA

Tissue

testis: 36 nTPM
liver: 5.5 nTPM
ovary: 5.2 nTPM
spinal cord: 4.9 nTPM
thyroid gland: 4.6 nTPM
fallopian tube: 4.5 nTPM

Single-cell type

early primary spermatocytes: 1,352 nCPM
differentiating spermatogonia: 186 nCPM
undifferentiated spermatogonia: 157 nCPM
neutrophils: 63 nCPM
late primary spermatocytes: 62 nCPM
late spermatids: 61 nCPM

Immune cell

eosinophil: 15 nTPM
memory B-cell: 14 nTPM
naive B-cell: 12 nTPM
non-classical monocyte: 9.6 nTPM
neutrophil: 5.3 nTPM
naive CD4 T-cell: 4.3 nTPM

Brain region

cerebellum: 9.9 nTPM
white matter: 7.9 nTPM
medulla oblongata: 6.6 nTPM
basal ganglia: 6.5 nTPM
pons: 6.5 nTPM
thalamus: 6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.97
gnomAD pLI: 0
gnomAD missense Z: 1.13
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

cell differentiation
epigenetic regulation of gene expression
homologous chromosome pairing at meiosis
meiosis I
positive regulation of double-strand break repair
spermatogenesis
positive regulation of DNA recombination

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZCWPW1 as an antibody target. Whether an autoantibody or antibody against ZCWPW1 could matter depends on whether native ZCWPW1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZCWPW1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZCWPW1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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