Seroatlas · Human Serome Atlas

ZCCHC9

Zinc finger CCHC domain-containing protein 9

Also known as: DKFZp761J139, PPP1R41, ZCHC9_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N567
Gene: ZCCHC9
Ensembl: ENSG00000131732
Chromosome: 5
Canonical length: 271 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli

OverviewNCBI Gene

Enables RNA binding activity. Located in nucleolus and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

271 residues, UniProt reviewed canonical sequence.

>Q8N567|ZCCHC9
     1  MTRWARVSTT YNKRPLPATS WEDMKKGSFE GTSQNLPKRK QLEANRLSLK NDAPQAKHKK
    61  NKKKKEYLNE DVNGFMEYLR QNSQMVHNGQ IIATDSEEVR EEIAVALKKD SRREGRRLKR
   121  QAAKKNAMVC FHCRKPGHGI ADCPAALENQ DMGTGICYRC GSTEHEITKC KAKVDPALGE
   181  FPFAKCFVCG EMGHLSRSCP DNPKGLYADG GGCKLCGSVE HLKKDCPESQ NSERMVTVGR
   241  WAKGMSADYE EILDVPKPQK PKTKIPKVVN F

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZCCHC9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.54
Highest tissue expression: 31 nTPM

Expression across tissuesHPA

Tissue

liver: 31 nTPM
placenta: 18 nTPM
lymph node: 18 nTPM
small intestine: 18 nTPM
ovary: 17 nTPM
tonsil: 17 nTPM

Single-cell type

hepatocytes: 89 nCPM
late primary spermatocytes: 84 nCPM
early spermatids: 79 nCPM
early primary spermatocytes: 76 nCPM
extravillous trophoblasts: 72 nCPM
hofbauer cells: 58 nCPM

Immune cell

T-reg: 18 nTPM
plasmacytoid DC: 15 nTPM
intermediate monocyte: 15 nTPM
memory CD4 T-cell: 14 nTPM
naive CD8 T-cell: 14 nTPM
non-classical monocyte: 14 nTPM

Brain region

choroid plexus: 9.3 nTPM
cerebellum: 9 nTPM
hypothalamus: 8.6 nTPM
thalamus: 8.6 nTPM
cerebral cortex: 8 nTPM
midbrain: 8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.92
gnomAD pLI: 0
gnomAD missense Z: 0.57
DepMap mean gene effect: -0.77
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Zinc finger, CCHC-type
Zinc finger, CCHC-type superfamily
Zinc knuckle
Zinc finger CCHC domain-containing protein 9

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZCCHC9 as an antibody target. Whether an autoantibody or antibody against ZCCHC9 could matter depends on whether native ZCCHC9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZCCHC9 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZCCHC9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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