ZCCHC24
Zinc finger CCHC domain-containing protein 24
Also known as: C10orf56, FLJ90798, Z3CXXC8, ZCH24_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8N2G6
- Gene
- ZCCHC24
- Ensembl
- ENSG00000165424
- Chromosome
- 10
- Canonical length
- 241 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Mitochondria
OverviewNCBI Gene
Enables RNA binding activity. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
241 residues, UniProt reviewed canonical sequence.
>Q8N2G6|ZCCHC24
1 MSLLSAIDTS AASVYQPAQL LNWVYLSLQD THQASAFDAF RPEPTAGAAP PELAFGKGRP
61 EQLGSPLHSS YLNSFFQLQR GEALSNSVYK GASPYGSLNN IADGLSSLTE HFSDLTLTSE
121 ARKPSKRPPP NYLCHLCFNK GHYIKDCPQA RPKGEGLTPY QGKKRCFGEY KCPKCKRKWM
181 SGNSWANMGQ ECIKCHINVY PHKQRPLEKP DGLDVSDQSK EHPQHLCEKC KVLGYYCRRV
241 QLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ZCCHC24 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.52
- Highest tissue expression
- 122 nTPM
Expression across tissuesHPA
Tissue
- spinal cord: 122 nTPM
- midbrain: 112 nTPM
- amygdala: 96 nTPM
- hippocampal formation: 93 nTPM
- basal ganglia: 83 nTPM
- hypothalamus: 66 nTPM
Single-cell type
- oligodendrocyte progenitor cells: 312 nCPM
- oligodendrocytes: 215 nCPM
- bergmann glia: 132 nCPM
- fibro-adipogenic progenitors: 129 nCPM
- schwann cells: 117 nCPM
- smooth muscle cells: 116 nCPM
Immune cell
- plasmacytoid DC: 0.9 nTPM
- classical monocyte: 0.6 nTPM
- myeloid DC: 0.4 nTPM
- intermediate monocyte: 0.3 nTPM
- gdT-cell: 0.2 nTPM
- NK-cell: 0.2 nTPM
Brain region
- basal ganglia: 246 nTPM
- white matter: 245 nTPM
- midbrain: 244 nTPM
- medulla oblongata: 225 nTPM
- thalamus: 224 nTPM
- spinal cord: 193 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.33
- gnomAD pLI
- 0.94
- gnomAD missense Z
- 1.91
- DepMap mean gene effect
- 0.08
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Molecular functions
Protein domainsUniProt · Pfam · InterPro
- Zinc finger, CCHC-type
- Zinc knuckle CX2CX3GHX4C
- ZAR1/RTP1-5-like, 3CxxC-type zinc finger
- Zinc finger, CCHC-type superfamily
- Zinc knuckle
- Zinc finger domain-containing protein 24, 3CxxC-type zinc finger
- Zinc finger domain-containing protein 24, C-terminal domain
- Zinc-binding domain
- ZCCHC24 C-terminal domain
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ZCCHC24 as an antibody target. Whether an autoantibody or antibody against ZCCHC24 could matter depends on whether native ZCCHC24 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ZCCHC24 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ZCCHC24 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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