Seroatlas · Human Serome Atlas

ZCCHC2

Zinc finger CCHC domain-containing protein 2

Also known as: C18orf49, FLJ20222, FLJ20281, KIAA1744, ZCHC2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9C0B9
Gene: ZCCHC2
Ensembl: ENSG00000141664
Chromosome: 18
Canonical length: 1178 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli,Nucleoli rim,Cytosol

OverviewNCBI Gene

Predicted to enable nucleic acid binding activity; phosphatidylinositol binding activity; and zinc ion binding activity. Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1178 residues, UniProt reviewed canonical sequence.

>Q9C0B9|ZCCHC2
     1  MLRMKLPLKP THPAEPPPEA EEPEADARPG AKAPSRRRRD CRPPPPPPPP AGPSRGPLPP
    61  PPPPRGLGPP VAGGAAAGAG MPGGGGGPSA ALREQERVYE WFGLVLGSAQ RLEFMCGLLD
   121  LCNPLELRFL GSCLEDLARK DYHYLRDSEA KANGLSDPGP LADFREPAVR SRLIVYLALL
   181  GSENREAAGR LHRLLPQVDS VLKSLRAARG EGSRGGAEDE RGEDGDGEQD AEKDGSGPEG
   241  GIVEPRVGGG LGSRAQEELL LLFTMASLHP AFSFHQRVTL REHLERLRAA LRGGPEDAEV
   301  EVEPCKFAGP RAQNNSAHGD YMQNNESSLI EQAPIPQDGL TVAPHRAQRE AVHIEKIMLK
   361  GVQRKRADKY WEYTFKVNWS DLSVTTVTKT HQELQEFLLK LPKELSSETF DKTILRALNQ
   421  GSLKREERRH PDLEPILRQL FSSSSQAFLQ SQKVHSFFQS ISSDSLHSIN NLQSSLKTSK
   481  ILEHLKEDSS EASSQEEDVL QHAIIHKKHT GKSPIVNNIG TSCSPLDGLT MQYSEQNGIV
   541  DWRKQSCTTI QHPEHCVTSA DQHSAEKRSL SSINKKKGKP QTEKEKIKKT DNRLNSRING
   601  IRLSTPQHAH GGTVKDVNLD IGSGHDTCGE TSSESYSSPS SPRHDGRESF ESEEEKDRDT
   661  DSNSEDSGNP STTRFTGYGS VNQTVTVKPP VQIASLGNEN GNLLEDPLNS PKYQHISFMP
   721  TLHCVMHNGA QKSEVVVPAP KPADGKTIGM LVPSPVAISA IRESANSTPV GILGPTACTG
   781  ESEKHLELLA SPLPIPSTFL PHSSTPALHL TVQRLKLPPP QGSSESCTVN IPQQPPGSLS
   841  IASPNTAFIP IHNPGSFPGS PVATTDPITK SASQVVGLNQ MVPQIEGNTG TVPQPTNVKV
   901  VLPAAGLSAA QPPASYPLPG SPLAAGVLPS QNSSVLSTAA TSPQPASAGI SQAQATVPPA
   961  VPTHTPGPAP SPSPALTHST AQSDSTSYIS AVGNTNANGT VVPPQQMGSG PCGSCGRRCS
  1021  CGTNGNLQLN SYYYPNPMPG PMYRVPSFFT LPSICNGSYL NQAHQSNGNQ LPFFLPQTPY
  1081  ANGLVHDPVM GSQANYGMQQ MAGFGRFYPV YPAPNVVANT SGSGPKKNGN VSCYNCGVSG
  1141  HYAQDCKQSS MEANQQGTYR LRYAPPLPPS NDTLDSAD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZCCHC2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.63
Highest tissue expression: 35 nTPM

Expression across tissuesHPA

Tissue

salivary gland: 35 nTPM
bone marrow: 25 nTPM
liver: 22 nTPM
blood vessel: 14 nTPM
skeletal muscle: 12 nTPM
testis: 11 nTPM

Single-cell type

salivary acinar cells: 252 nCPM
late spermatids: 223 nCPM
innate lymphoid cells: 198 nCPM
lactotrophs: 163 nCPM
early spermatids: 152 nCPM
somatotrophs: 150 nCPM

Immune cell

neutrophil: 1.5 nTPM
eosinophil: 0.8 nTPM
naive CD4 T-cell: 0.6 nTPM
gdT-cell: 0.5 nTPM
intermediate monocyte: 0.5 nTPM
MAIT T-cell: 0.4 nTPM

Brain region

white matter: 36 nTPM
cerebellum: 32 nTPM
cerebral cortex: 30 nTPM
medulla oblongata: 29 nTPM
midbrain: 28 nTPM
hypothalamus: 28 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.28
gnomAD pLI: 0.99
gnomAD missense Z: 0.45
DepMap mean gene effect: 0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

Zinc finger, CCHC-type
PX domain superfamily
Zinc finger, CCHC-type superfamily
RNA-binding protein vts1-like, alpha-helical domain
SMAUG/ZCCHC2-like, PHAT domain
Zinc knuckle
RNA-binding protein vts1-like domain
SMAUG-like PHAT domain
Zinc finger CCHC domain-containing protein 2

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZCCHC2 as an antibody target. Whether an autoantibody or antibody against ZCCHC2 could matter depends on whether native ZCCHC2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZCCHC2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZCCHC2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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