Seroatlas · Human Serome Atlas

ZCCHC14

Zinc finger CCHC domain-containing protein 14

Also known as: BDG29, MGC14139, ZCH14_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WYQ9
Gene: ZCCHC14
Ensembl: ENSG00000140948
Chromosome: 16
Canonical length: 949 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nuclear membrane

OverviewNCBI Gene

Predicted to enable nucleic acid binding activity; phosphatidylinositol binding activity; and zinc ion binding activity. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

949 residues, UniProt reviewed canonical sequence.

>Q8WYQ9|ZCCHC14
     1  MASNHPAFSF HQKQVLRQEL TQIQSSLNGG GGHGGKGAPG PGGALPTCPA CHKITPRTEA
    61  PVSSVSNSLE NALHTSAHST EESLPKRPLG KHSKVSVEKI DLKGLSHTKN DRNVECSFEV
   121  LWSDSSITSV TKSSSEVTEF ISKLCQLYPE ENLEKLIPCL AGPDAFYVER NHVDLDSGLR
   181  YLASLPSHVL KNDHVRRFLS TSSPPQQLQS PSPGNPSLSK VGTVMGVSGR PVCGVAGIPS
   241  SQSGAQHHGQ HPAGSAAPLP HCSHAGSAGS ALAYRTQMDT SPAILMPSSL QTPQTQEQNG
   301  ILDWLRKLRL HKYYPVFKQL SMEKFLSLTE EDLNKFESLT MGAKKKLKTQ LELEKEKSER
   361  RCLNPSAPPL VTSSGVARVP PTSHVGPVQS GRGSHAAELR VEVEQPHHQL PREGSSSEYS
   421  SSSSSPMGVQ AREESSDSAE ENDRRVEIHL ESSDKEKPVM LLNHFTSSSA RPTAQVLPVQ
   481  NEASSNPSGH HPLPPQMLSA ASHITPIRML NSVHKPERGS ADMKLLSSSV HSLLSLEERN
   541  KGSGPRSSMK VDKSFGSAMM DVLPASAPHQ PVQVLSGLSE SSSMSPTVSF GPRTKVVHAS
   601  TLDRVLKTAQ QPALVVETST AATGTPSTVL HAARPPIKLL LSSSVPADSA ISGQTSCPNN
   661  VQISVPPAII NPRTALYTAN TKVAFSAMSS MPVGPLQGGF CANSNTASPS SHPSTSFANM
   721  ATLPSCPAPS SSPALSSVPE SSFYSSSGGG GSTGNIPASN PNHHHHHHHQ QPPAPPQPAP
   781  PPPGCIVCTS CGCSGSCGSS GLTVSYANYF QHPFSGPSVF TFPFLPFSPM CSSGYVSAQQ
   841  YGGGSTFPVV HAPYSSSGTP DPVLSGQSTF AVPPMQNFMA GTAGVYQTQG LVGSSNGSSH
   901  KKSGNLSCYN CGATGHRAQD CKQPSMDFNR PGTFRLKYAP PAESLDSTD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZCCHC14 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.64
Highest tissue expression: 33 nTPM

Expression across tissuesHPA

Tissue

testis: 33 nTPM
liver: 22 nTPM
cerebellum: 19 nTPM
blood vessel: 17 nTPM
small intestine: 13 nTPM
adrenal gland: 13 nTPM

Single-cell type

proximal tubule cells: 137 nCPM
renal collecting duct intercalated cells: 118 nCPM
retinal horizontal cells: 116 nCPM
choroid plexus epithelial cells: 111 nCPM
adrenal cortex cells: 110 nCPM
somatotrophs: 108 nCPM

Immune cell

MAIT T-cell: 0.5 nTPM
non-classical monocyte: 0.5 nTPM
naive CD4 T-cell: 0.4 nTPM
T-reg: 0.4 nTPM
memory CD8 T-cell: 0.3 nTPM
gdT-cell: 0.2 nTPM

Brain region

cerebellum: 52 nTPM
hippocampal formation: 40 nTPM
cerebral cortex: 37 nTPM
amygdala: 36 nTPM
basal ganglia: 32 nTPM
thalamus: 32 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.31
gnomAD pLI: 0.98
gnomAD missense Z: 0.81
DepMap mean gene effect: 0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Protein domainsUniProt · Pfam · InterPro

Sterile alpha motif domain
Zinc finger, CCHC-type
Sterile alpha motif/pointed domain superfamily
PX domain superfamily
Zinc finger, CCHC-type superfamily
Zinc knuckle
SAM domain (Sterile alpha motif)
ZCCH14, SAM domain
Zinc finger CCHC domain-containing protein 14

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZCCHC14 as an antibody target. Whether an autoantibody or antibody against ZCCHC14 could matter depends on whether native ZCCHC14 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZCCHC14 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZCCHC14 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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