Seroatlas · Human Serome Atlas

ZCCHC13

Zinc finger CCHC domain-containing protein 13

Also known as: 4930513O09RIK, Cnbp2, ZCH13_HUMAN, ZNF9L

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WW36
Gene: ZCCHC13
Ensembl: ENSG00000187969
Chromosome: X
Canonical length: 166 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

This gene appears to represent an intronless retrocopy of a related multi-exon gene located on chromosome 3. However, the CDS of this intronless gene remains relatively intact, it is conserved in other mammalian species, it is known to be transcribed, and it is therefore thought to encode a functional protein. The encoded protein contains six CCHC-type zinc fingers, and is thus thought to function as a transcription factor. [provided by RefSeq, May 2010]

Canonical amino-acid sequenceUniProt

166 residues, UniProt reviewed canonical sequence.

>Q8WW36|ZCCHC13
     1  MSSKDFFACG HSGHWARGCP RGGAGGRRGG GHGRGSQCGS TTLSYTCYCC GESGRNAKNC
    61  VLLGNICYNC GRSGHIAKDC KDPKRERRQH CYTCGRLGHL ARDCDRQKEQ KCYSCGKLGH
   121  IQKDCAQVKC YRCGEIGHVA INCSKARPGQ LLPLRQIPTS SQGMSQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZCCHC13 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.53
Highest tissue expression: 21 nTPM

Expression across tissuesHPA

Tissue

testis: 21 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM

Single-cell type

late spermatids: 994 nCPM
early spermatids: 267 nCPM
late primary spermatocytes: 90 nCPM
sertoli cells: 2.2 nCPM
leydig cells: 2.1 nCPM
peritubular myoid cells: 1.9 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.86
gnomAD pLI: 0
gnomAD missense Z: 0.71
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

positive regulation of cytoplasmic translation

Molecular functions

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZCCHC13 as an antibody target. Whether an autoantibody or antibody against ZCCHC13 could matter depends on whether native ZCCHC13 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZCCHC13 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZCCHC13 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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