Seroatlas · Human Serome Atlas

ZC3H7B

Zinc finger CCCH domain-containing protein 7B

Also known as: DKFZp434K0920, FLJ13787, KIAA1031, RoXaN, Z3H7B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UGR2
Gene: ZC3H7B
Ensembl: ENSG00000100403
Chromosome: 22
Canonical length: 977 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

This gene encodes a protein that contains a tetratricopeptide repeat domain. The encoded protein also interacts with the rotavirus non-structural protein NSP3. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

977 residues, UniProt reviewed canonical sequence.

>Q9UGR2|ZC3H7B
     1  MERQKRKADI EKGLQFIQST LPLKQEEYEA FLLKLVQNLF AEGNDLFREK DYKQALVQYM
    61  EGLNVADYAA SDQVALPREL LCKLHVNRAA CYFTMGLYEK ALEDSEKALG LDSESIRALF
   121  RKARALNELG RHKEAYECSS RCSLALPHDE SVTQLGQELA QKLGLRVRKA YKRPQELETF
   181  SLLSNGTAAG VADQGTSNGL GSIDDIETDC YVDPRGSPAL LPSTPTMPLF PHVLDLLAPL
   241  DSSRTLPSTD SLDDFSDGDV FGPELDTLLD SLSLVQGGLS GSGVPSELPQ LIPVFPGGTP
   301  LLPPVVGGSI PVSSPLPPAS FGLVMDPSKK LAASVLDALD PPGPTLDPLD LLPYSETRLD
   361  ALDSFGSTRG SLDKPDSFME ETNSQDHRPP SGAQKPAPSP EPCMPNTALL IKNPLAATHE
   421  FKQACQLCYP KTGPRAGDYT YREGLEHKCK RDILLGRLRS SEDQTWKRIR PRPTKTSFVG
   481  SYYLCKDMIN KQDCKYGDNC TFAYHQEEID VWTEERKGTL NRDLLFDPLG GVKRGSLTIA
   541  KLLKEHQGIF TFLCEICFDS KPRIISKGTK DSPSVCSNLA AKHSFYNNKC LVHIVRSTSL
   601  KYSKIRQFQE HFQFDVCRHE VRYGCLREDS CHFAHSFIEL KVWLLQQYSG MTHEDIVQES
   661  KKYWQQMEAH AGKASSSMGA PRTHGPSTFD LQMKFVCGQC WRNGQVVEPD KDLKYCSAKA
   721  RHCWTKERRV LLVMSKAKRK WVSVRPLPSI RNFPQQYDLC IHAQNGRKCQ YVGNCSFAHS
   781  PEERDMWTFM KENKILDMQQ TYDMWLKKHN PGKPGEGTPI SSREGEKQIQ MPTDYADIMM
   841  GYHCWLCGKN SNSKKQWQQH IQSEKHKEKV FTSDSDASGW AFRFPMGEFR LCDRLQKGKA
   901  CPDGDKCRCA HGQEELNEWL DRREVLKQKL AKARKDMLLC PRDDDFGKYN FLLQEDGDLA
   961  GATPEAPAAA ATATTGE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZC3H7B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 53 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 53 nTPM
cerebellum: 46 nTPM
thyroid gland: 44 nTPM
salivary gland: 42 nTPM
parathyroid gland: 42 nTPM
spinal cord: 42 nTPM

Single-cell type

adrenal cortex cells: 99 nCPM
retinal pigment epithelial cells: 94 nCPM
leydig cells: 75 nCPM
podocytes: 69 nCPM
retinal horizontal cells: 68 nCPM
hepatocytes: 67 nCPM

Immune cell

memory B-cell: 0.3 nTPM
naive B-cell: 0.3 nTPM
NK-cell: 0.3 nTPM
plasmacytoid DC: 0.3 nTPM
memory CD4 T-cell: 0.2 nTPM
memory CD8 T-cell: 0.2 nTPM

Brain region

pons: 144 nTPM
medulla oblongata: 120 nTPM
cerebral cortex: 110 nTPM
hypothalamus: 103 nTPM
amygdala: 100 nTPM
thalamus: 99 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.32
gnomAD pLI: 0.93
gnomAD missense Z: 2.87
DepMap mean gene effect: 0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZC3H7B as an antibody target. Whether an autoantibody or antibody against ZC3H7B could matter depends on whether native ZC3H7B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZC3H7B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZC3H7B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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