Seroatlas · Human Serome Atlas

ZC3H7A

Zinc finger CCCH domain-containing protein 7A

Also known as: FLJ20318, HSPC055, Z3H7A_HUMAN, ZC3H7, ZC3HDC7

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IWR0
Gene: ZC3H7A
Ensembl: ENSG00000122299
Chromosome: 16
Canonical length: 971 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Enables miRNA binding activity. Involved in miRNA processing. Acts upstream of with a positive effect on post-transcriptional regulation of gene expression. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

971 residues, UniProt reviewed canonical sequence.

>Q8IWR0|ZC3H7A
     1  MSNVSEERRK RQQNIKEGLQ FIQSPLSYPG TQEQYAVYLR ALVRNLFNEG NDVYREHDWN
    61  NSISQYTEAL NIADYAKSEE ILIPKEIIEK LYINRIACYS NMGFHDKVLE DCNIVLSLNA
   121  SNCKALYRKS KALSDLGRYK KAYDAVAKCS LAVPQDEHVI KLTQELAQKL GFKIRKAYVR
   181  AELSLKSVPG DGATKALNHS VEDIEPDLLT PRQEAVPVVS LPAPSFSHEV GSELASVPVM
   241  PLTSILPLQV EESALPSAVL ANGGKMPFTM PEAFLDDGDM VLGDELDDLL DSAPETNETV
   301  MPSALVRGPL QTASVSPSMP FSASLLGTLP IGARYAPPPS FSEFYPPLTS SLEDFCSSLN
   361  SFSMSESKRD LSTSTSREGT PLNNSNSSLL LMNGPGSLFA SENFLGISSQ PRNDFGNFFG
   421  SAVTKPSSSV TPRHPLEGTH ELRQACQICF VKSGPKLMDF TYHANIDHKC KKDILIGRIK
   481  NVEDKSWKKI RPRPTKTNYE GPYYICKDVA AEEECRYSGH CTFAYCQEEI DVWTLERKGA
   541  FSREAFFGGN GKINLTVFKL LQEHLGEFIF LCEKCFDHKP RMISKRNKDN STACSHPVTK
   601  HEFEDNKCLV HILRETTVKY SKIRSFHGQC QLDLCRHEVR YGCLREDECF YAHSLVELKV
   661  WIMQNETGIS HDAIAQESKR YWQNLEANVP GAQVLGNQIM PGFLNMKIKF VCAQCLRNGQ
   721  VIEPDKNRKY CSAKARHSWT KDRRAMRVMS IERKKWMNIR PLPTKKQMPL QFDLCNHIAS
   781  GKKCQYVGNC SFAHSPEERE VWTYMKENGI QDMEQFYELW LKSQKNEKSE DIASQSNKEN
   841  GKQIHMPTDY AEVTVDFHCW MCGKNCNSEK QWQGHISSEK HKEKVFHTED DQYCWQHRFP
   901  TGYFSICDRY MNGTCPEGNS CKFAHGNAEL HEWEERRDAL KMKLNKARKD HLIGPNDNDF
   961  GKYSFLFKDL N

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZC3H7A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 36 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 36 nTPM
skeletal muscle: 31 nTPM
blood vessel: 28 nTPM
salivary gland: 28 nTPM
retina: 28 nTPM
lymph node: 27 nTPM

Single-cell type

neutrophils: 176 nCPM
retinal pigment epithelial cells: 162 nCPM
neutrophil progenitors: 151 nCPM
choroid plexus epithelial cells: 151 nCPM
salivary acinar cells: 125 nCPM
platelets: 117 nCPM

Immune cell

non-classical monocyte: 32 nTPM
T-reg: 24 nTPM
NK-cell: 22 nTPM
naive CD4 T-cell: 21 nTPM
eosinophil: 21 nTPM
MAIT T-cell: 20 nTPM

Brain region

choroid plexus: 60 nTPM
cerebellum: 41 nTPM
white matter: 36 nTPM
thalamus: 33 nTPM
medulla oblongata: 31 nTPM
basal ganglia: 31 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.12
gnomAD pLI: 1
gnomAD missense Z: 1.75
DepMap mean gene effect: 0
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZC3H7A as an antibody target. Whether an autoantibody or antibody against ZC3H7A could matter depends on whether native ZC3H7A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZC3H7A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZC3H7A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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