Seroatlas · Human Serome Atlas

ZC3H6

Zinc finger CCCH domain-containing protein 6

Also known as: FLJ41410, FLJ45877, KIAA2035, ZC3H6_HUMAN, ZC3HDC6

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P61129
Gene: ZC3H6
Ensembl: ENSG00000188177
Chromosome: 2
Canonical length: 1189 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Golgi apparatus

OverviewNCBI Gene

Predicted to enable RNA binding activity and zinc ion binding activity. Predicted to be involved in negative regulation of DNA-templated transcription. Predicted to be located in chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1189 residues, UniProt reviewed canonical sequence.

>P61129|ZC3H6
     1  MTDSEHAGHD REDGELEDGE IDDAGFEEIQ EKEAKENEKQ KSEKAYRKSR KKHKKEREKK
    61  KSKRRKREKH KHNSPSSDDS SDYSLDSDVE HTESSHKKRT GFYRDYDIPF TQRGHISGSY
   121  ITSKKGQHNK KFKSKEYDEY STYSDDNFGN YSDDNFGNYG QETEEDFANQ LKQYRQAKET
   181  SNIALGSSFS KESGKKQRMK GVQQGIEQRV KSFNVGRGRG LPKKIKRKER GGRTNKGPNV
   241  FSVSDDFQEY NKPGKKWKVM TQEFINQHTV EHKGKQICKY FLEGRCIKGD QCKFDHDAEL
   301  EKRKEICKFY LQGYCTKGEN CIYMHNEFPC KFYHSGAKCY QGDNCKFSHD DLTKETKKLL
   361  DKVLNTDEEL INEDERELEE LRKRGITPLP KPPPGVGLLP TPPEHFPFSD PEDDFQTDFS
   421  DDFRKIPSLF EIVVKPTVDL AHKIGRKPPA FYTSASPPGP QFQGSSPHPQ HIYSSGSSPG
   481  PGPNMSQGHS SPVMHPGSPG HHPCAGPPGL PVPQSPPLPP GPPEIVGPQN QAGVLVQPDT
   541  SLTPPSMGGA YHSPGFPGHV MKVPRENHCS PGSSYQQSPG EMQLNTNYES LQNPAEFYDN
   601  YYAQHSIHNF QPPNNSGDGM WHGEFAQQQP PVVQDSPNHG SGSDGSSTRT GHGPLPVPGL
   661  LPAVQRALFV RLTQRYQEDE EQTSTQPHRA PSKEEDDTVN WYSSSEEEEG SSVKSILKTL
   721  QKQTETLRNQ QQPSTELSTP TDPRLAKEKS KGNQVVDPRL RTIPRQDIRK PSESAPLDLR
   781  LAWDPRKLRG NGSGHIGSSV GGAKFDLHHA NAGTNVKHKR GDDDDEDTER ELREKAFLIP
   841  LDASPGIMLQ DPRSQLRQFS HIKMDITLTK PNFAKHIVWA PEDLLPVPLP KPDPVSSINL
   901  PLPPLIADQR LNRLWNTKSD LHQNTVSIDP KLAAKAKINT TNREGYLEQF GDSHGSGAKL
   961  GDPRLQKNFD PRLHRLPNTE SHQVVMKDSH ASKGAPHLPR SNPGSSQPSG AGTSNSGSGA
  1021  LPPYAPKLSS SAGLPLGTST SVLSGISLYD PRDHGSSSTS ELATASSGEN SKNQKKSGGL
  1081  KSSDKTEPSP GEAILPQKPS PNVGVTLEGP ADPQADVPRS SGKVQVPAVH SLPVQALTGL
  1141  IRPQYSDPRQ ARQPGQGSPT PDNDPGRETD DKSLKEVFKT FDPTASPFC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZC3H6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.66
Highest tissue expression: 8.6 nTPM

Expression across tissuesHPA

Tissue

retina: 8.6 nTPM
skeletal muscle: 5.4 nTPM
tongue: 5.3 nTPM
ovary: 4.5 nTPM
skin: 4.2 nTPM
cerebellum: 3.9 nTPM

Single-cell type

corticotrophs: 179 nCPM
thyrotrophs: 177 nCPM
myonuclei: 168 nCPM
ependymal cells: 157 nCPM
medullary thymic epithelial cells: 156 nCPM
pituitary stem cells: 143 nCPM

Immune cell

naive B-cell: 1.7 nTPM
naive CD4 T-cell: 1.4 nTPM
memory B-cell: 1.3 nTPM
memory CD4 T-cell: 1.3 nTPM
non-classical monocyte: 1.3 nTPM
naive CD8 T-cell: 1.2 nTPM

Brain region

cerebellum: 20 nTPM
white matter: 19 nTPM
basal ganglia: 17 nTPM
cerebral cortex: 17 nTPM
midbrain: 15 nTPM
amygdala: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.41
gnomAD pLI: 0.19
gnomAD missense Z: 1.47
DepMap mean gene effect: -0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

negative regulation of DNA-templated transcription

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZC3H6 as an antibody target. Whether an autoantibody or antibody against ZC3H6 could matter depends on whether native ZC3H6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZC3H6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZC3H6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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