Seroatlas · Human Serome Atlas

ZC3H13

Zinc finger CCCH domain-containing protein 13

Also known as: DKFZp434D1812, KIAA0853, Xio, ZC3HD_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5T200
Gene
ZC3H13
Ensembl
ENSG00000123200
Chromosome
13
Canonical length
1668 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

Enables RNA binding activity. Involved in mRNA processing. Located in nuclear speck. Part of RNA N6-methyladenosine methyltransferase complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1668 residues, UniProt reviewed canonical sequence.

>Q5T200|ZC3H13
     1  MSKIRRKVTV ENTKTISDST SRRPSVFERL GPSTGSTAET QCRNWLKTGN CLYGNTCRFV
    61  HGPSPRGKGY SSNYRRSPER PTGDLRERMK NKRQDVDTEP QKRNTEESSS PVRKESSRGR
   121  HREKEDIKIT KERTPESEEE NVEWETNRDD SDNGDINYDY VHELSLEMKR QKIQRELMKL
   181  EQENMEKREE IIIKKEVSPE VVRSKLSPSP SLRKSSKSPK RKSSPKSSSA SKKDRKTSAV
   241  SSPLLDQQRN SKTNQSKKKG PRTPSPPPPI PEDIALGKKY KEKYKVKDRI EEKTRDGKDR
   301  GRDFERQREK RDKPRSTSPA GQHHSPISSR HHSSSSQSGS SIQRHSPSPR RKRTPSPSYQ
   361  RTLTPPLRRS ASPYPSHSLS SPQRKQSPPR HRSPMREKGR HDHERTSQSH DRRHERREDT
   421  RGKRDREKDS REEREYEQDQ SSSRDHRDDR EPRDGRDRRD ARDTRDRREL RDSRDMRDSR
   481  EMRDYSRDTK ESRDPRDSRS TRDAHDYRDR EGRDTHRKED TYPEESRSYG RNHLREESSR
   541  TEIRNESRNE SRSEIRNDRM GRSRGRVPEL PEKGSRGSRG SQIDSHSSNS NYHDSWETRS
   601  SYPERDRYPE RDNRDQARDS SFERRHGERD RRDNRERDQR PSSPIRHQGR NDELERDERR
   661  EERRVDRVDD RRDERARERD RERERDRERE RERERERDRE REKERELERE RARERERERE
   721  KERDRERDRD RDHDRERERE RERDREKERE REREERERER ERERERERER ERERERARER
   781  DKERERQRDW EDKDKGRDDR REKREEIRED RNPRDGHDER KSKKRYRNEG SPSPRQSPKR
   841  RREHSPDSDA YNSGDDKNEK HRLLSQVVRP QESRSLSPSH LTEDRQGRWK EEDRKPERKE
   901  SSRRYEEQEL KEKVSSVDKQ REQTEILESS RMRAQDIIGH HQSEDRETSD RAHDENKKKA
   961  KIQKKPIKKK KEDDVGIERG NIETTSEDGQ VFSPKKGQKK KSIEKKRKKS KGDSDISDEE
  1021  AAQQSKKKRG PRTPPITTKE ELVEMCNGKN GILEDSQKKE DTAFSDWSDE DVPDRTEVTE
  1081  AEHTATATTP GSTPSPLSSL LPPPPPVATA TATTVPATLA ATTAAAATSF STSAITISTS
  1141  ATPTNTTNNT FANEDSHRKC HRTRVEKVET PHVTIEDAQH RKPMDQKRSS SLGSNRSNRS
  1201  HTSGRLRSPS NDSAHRSGDD QSGRKRVLHS GSRDREKTKS LEITGERKSR IDQLKRGEPS
  1261  RSTSSDRQDS RSHSSRRSSP ESDRQVHSRS GSFDSRDRLQ ERDRYEHDRE RERERRDTRQ
  1321  REWDRDADKD WPRNRDRDRL RERERERERD KRRDLDRERE RLISDSVERD RDRDRDRTFE
  1381  SSQIESVKRC EAKLEGEHER DLESTSRDSL ALDKERMDKD LGSVQGFEET NKSERTESLE
  1441  GDDESKLDDA HSLGSGAGEG YEPISDDELD EILAGDAEKR EDQQDEEKMP DPLDVIDVDW
  1501  SGLMPKHPKE PREPGAALLK FTPGAVMLRV GISKKLAGSE LFAKVKETCQ RLLEKPKDAD
  1561  NLFEHELGAL NMAALLRKEE RASLLSNLGP CCKALCFRRD SAIRKQLVKN EKGTIKQAYT
  1621  SAPMVDNELL RLSLRLFKRK TTCHAPGHEK TEDNKLSQSS IQQELCVS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZC3H13 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.65
Highest tissue expression
55 nTPM

Expression across tissuesHPA

Tissue

  • liver: 55 nTPM
  • thymus: 21 nTPM
  • cerebral cortex: 18 nTPM
  • endometrium: 17 nTPM
  • blood vessel: 17 nTPM
  • parathyroid gland: 17 nTPM

Single-cell type

  • hepatocytes: 494 nCPM
  • early primary spermatocytes: 221 nCPM
  • erythrocyte progenitors: 211 nCPM
  • neutrophils: 191 nCPM
  • oligodendrocytes: 180 nCPM
  • megakaryocyte-erythroid progenitors: 166 nCPM

Immune cell

  • basophil: 15 nTPM
  • eosinophil: 11 nTPM
  • NK-cell: 8.9 nTPM
  • plasmacytoid DC: 7.9 nTPM
  • neutrophil: 7.7 nTPM
  • gdT-cell: 7.4 nTPM

Brain region

  • white matter: 68 nTPM
  • basal ganglia: 68 nTPM
  • thalamus: 64 nTPM
  • hypothalamus: 64 nTPM
  • midbrain: 63 nTPM
  • amygdala: 58 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.21
gnomAD pLI
1
gnomAD missense Z
1.73
DepMap mean gene effect
-0.47
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZC3H13 as an antibody target. Whether an autoantibody or antibody against ZC3H13 could matter depends on whether native ZC3H13 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZC3H13 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZC3H13 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZC3H13. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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