Seroatlas · Human Serome Atlas

ZC3H11C

Zinc finger CCCH domain-containing protein 11C

Also known as: ZC11C_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0DQW0
Gene: ZC3H11C
Canonical length: 805 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for ZC3H11C in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

805 residues, UniProt reviewed canonical sequence.

>P0DQW0|ZC3H11C
     1  MPNQGEDCYF FFYSTCTKGD SCPFRHCEAA LGNETVCTLW QEGRCFRRVC RFRHMEIDKK
    61  RSEIPCYWEN QPTGCQKLNC AFHHNRGRYV DGLFLPPSKS VLPTVPESPE EEVKASQLSV
   121  QQNKLSVQSN PSPQLRSVMK VESSENVPSP KHPPVVINAA DDDEDDDDQF SEEGDETKTP
   181  TLQPTPEVHN GLRVTSVRKP AVNIKQGECL HFGIKTLEEI KSKKMKEKSE EQGEGSSGVS
   241  SLLLHPEPVP GPEKENVRTV VRTVTLSTKQ GEEPLVRLGL TETLGKRKFS TGGDSDPPLK
   301  RSLAQRLGKK VEAPETNTDE TPKKAQVSKS LKERLGMSAD PNNEDATDKV NKVGEIHVKT
   361  LEEMLLERAS QKHGESQTKL KTEGPSKTDD STSGARSSST IRIKTFSEVL AEEEHRQQEA
   421  ERQKSKKDTT CIKLKTDSEI KKTVVLPPIV ASKGQSEEPA GKTKSMQEVH MKTVEEIKLE
   481  KALRVQQSSE SSTSSPSQHE ATPGARLLLR ITKRTWRKEE KKLQEGNEVD FLSRVRMEAT
   541  EASVETTGVD ITKIQVKRCE IMRETRMQKQ QEREKSVLTP LQGDVASCNT QVAEKPVLTA
   601  VPGITWHLTK QLPTKSSQKV EVETSGIADS LLNVKWSAQT LEKRGEAKPT VNVKQSVVKV
   661  VSSPKLAPKR KAVEMHPAVT AAVKPLSSSS VLQEPPAKKA AVDAVVLLVS EDKSVTVPET
   721  ENPRDSLVLP LTQSSSDSSP PEVSGPSSSQ MSMKTRRLSS ASTGKPPLSV EDDFEKLTWE
   781  ISGGKLEAEI DLDPGKDEDD LPLEL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZC3H11C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.66
Highest tissue expression: 5.1 nTPM

Expression across tissuesHPA

Tissue

testis: 5.1 nTPM
retina: 1.1 nTPM
skin: 0.8 nTPM
skeletal muscle: 0.6 nTPM
lymph node: 0.5 nTPM
adrenal gland: 0.4 nTPM

Single-cell type

late primary spermatocytes: 20 nCPM
early spermatids: 13 nCPM
cone photoreceptor cells: 6.2 nCPM
neutrophils: 5.1 nCPM
neutrophil progenitors: 4.8 nCPM
paneth cells: 3.9 nCPM

Immune cell

basophil: 0.1 nTPM
gdT-cell: 0.1 nTPM
MAIT T-cell: 0.1 nTPM
memory CD8 T-cell: 0.1 nTPM
naive CD4 T-cell: 0.1 nTPM
naive CD8 T-cell: 0.1 nTPM

Brain region

choroid plexus: 0.5 nTPM
white matter: 0.5 nTPM
basal ganglia: 0.4 nTPM
cerebellum: 0.4 nTPM
cerebral cortex: 0.4 nTPM
hypothalamus: 0.4 nTPM

OntologyGO

Biological processes

poly(A)+ mRNA export from nucleus

Molecular functions

zinc ion binding

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZC3H11C as an antibody target. Whether an autoantibody or antibody against ZC3H11C could matter depends on whether native ZC3H11C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZC3H11C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZC3H11C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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