Seroatlas · Human Serome Atlas

ZC3H11B

Zinc finger CCCH domain-containing protein 11B

Also known as: ZC11B_HUMAN, ZC3HDC11B

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A0A1B0GTU1
Gene: ZC3H11B
Ensembl: ENSG00000215817
Chromosome: 1
Canonical length: 805 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nuclear speckles

OverviewNCBI Gene

Predicted to enable zinc ion binding activity. Predicted to be involved in poly(A)+ mRNA export from nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

805 residues, UniProt reviewed canonical sequence.

>A0A1B0GTU1|ZC3H11B
     1  MPNQGEDCYF FFYSTCTKGD SCPFRHCEAA LGNETVCTLW QEGRCFRRVC RFRHMEIDKK
    61  RSEIPCYWEN QPTGCQKLNC VFHHNRGRYV DGLFLPPSKS VLPTVPESPE EEVKASQLSV
   121  QQNKLSVQSN TSPQLRSVMK VESSENVPSP KHPPVVINAA DDDEDDDDQF SEEGDETKTP
   181  TLQPTPEVHN GLRVTSVRKP AVNIKQGECL HFGIKTLEEI KSKKMKEKSE EQGEGSSGVS
   241  SLLLHPEPVP GPEKENVRTV VRTVTLSTKQ GEEPLVRLGL TETLGKRKFS TGGDSDPPLK
   301  RSLAQRLGKK VEAPETNTDE TPKKAQVSKS LKERLGMSAD PNNEDATDKV NKVGEIHVKT
   361  LEEMLLERAS QKHGESQTKL KTEGPSKTDD STSGARSSST IRIKTFSEVL AEEEHRQQEA
   421  ERQKSKKDTT CIKLKTDSEI KKTVVLPPIV ASKGQSEEPA GKTKSMQEVH MKTVEEIKLE
   481  KALRVQQSSE SSTSSPSQHE ATPGARLLLR ITKRTWRKEE KKLQEGNEVD FLSRVRMEAT
   541  EASVETTGVD ITKIQVKRCE IMRETRMQKQ QEREKSVLTP LQGDVASCNT QVAEKPVLTA
   601  VPGITWHLTK QLPTKSSQKV EVETSGIADS LLNVKWSAQT LEKRGEAKPT VNVKQSVVKV
   661  VSSPKLAPKR KAVEMHPAVT AAVKPLSSSS VLQEPPAKKA AVDAVVLLDS EDKSVTVPEA
   721  ENPRDSLVLP PTQSSSDSSP PEVSGPSSSQ MSMKTRRLSS ASTGKPPLSV EDDFEKLTWE
   781  ISGGKLEAEI DLDPGKDEDD LPLEL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZC3H11B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.66
Highest tissue expression: 5.4 nTPM

Expression across tissuesHPA

Tissue

testis: 5.4 nTPM
heart muscle: 0.3 nTPM
adipose tissue: 0.2 nTPM
adrenal gland: 0.2 nTPM
cerebellum: 0.2 nTPM
endometrium: 0.2 nTPM

Single-cell type

proximal tubule cells: 14 nCPM
late primary spermatocytes: 13 nCPM
distal convoluted tubule cells: 9.3 nCPM
renal collecting duct intercalated cells: 9.3 nCPM
renal connecting tubule cells: 8.8 nCPM
loop of henle epithelial cells: 8.7 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

medulla oblongata: 0.1 nTPM
thalamus: 0.1 nTPM
amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM

OntologyGO

Biological processes

poly(A)+ mRNA export from nucleus

Molecular functions

zinc ion binding

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZC3H11B as an antibody target. Whether an autoantibody or antibody against ZC3H11B could matter depends on whether native ZC3H11B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZC3H11B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZC3H11B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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