Seroatlas · Human Serome Atlas

ZC2HC1C

Zinc finger C2HC domain-containing protein 1C

Also known as: C14orf140, FAM164C, ZC21C_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q53FD0
Gene: ZC2HC1C
Ensembl: ENSG00000119703
Chromosome: 14
Canonical length: 456 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nuclear speckles,Mitochondria

OverviewNCBI Gene

Predicted to enable zinc ion binding activity. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

456 residues, UniProt reviewed canonical sequence.

>Q53FD0|ZC2HC1C
     1  MAGLQRLASH LPVGVMLPHN TTEAPGPHSA KQDSYEQGDS SQQSLKGHLR NNFQKQLLSN
    61  KELILDKVYT HPKWNTQTKA RSYSYPHCTG ISQQDPESDS QGQGNGLFYS SGPQSWYPKA
   121  NNQDFIPFTK KRVGVDRAFP LKPMVHRKSC STGEAGTDGD HNVYPRPPEP REFSSRNFGV
   181  RNQGNFSVVG TVLAATQAEK AVANFDRTEW VQIRRLEAAG ESLEEEIRRK QILLRGKLKK
   241  TEEELRRIQT QKEQAKENEN GELQKIILPR SRVKGNKSNT MYKPIFSPEF EFEEEFSRDR
   301  REDETWGRSQ QNSGPFQFSD YRIQRLKRER LVASNNKIRD PVSEPSVEKF SPPSETPVGA
   361  LQGSARNSSL SMAPDSSGSS GSIEEPQLGE CSHCGRKFLS FRLERHSNIC SRMRGSKRKV
   421  FDSSRARAKG TELEQYLNWK GPASAKAEPP QKSNWR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZC2HC1C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.65
Highest tissue expression: 52 nTPM

Expression across tissuesHPA

Tissue

testis: 52 nTPM
epididymis: 23 nTPM
fallopian tube: 10 nTPM
choroid plexus: 8.2 nTPM
liver: 7.9 nTPM
thyroid gland: 6.6 nTPM

Single-cell type

late primary spermatocytes: 438 nCPM
cardiomyocytes: 302 nCPM
late spermatids: 280 nCPM
myonuclei: 190 nCPM
epicardial cells: 162 nCPM
early spermatids: 118 nCPM

Immune cell

NK-cell: 1.3 nTPM
T-reg: 0.9 nTPM
gdT-cell: 0.6 nTPM
memory B-cell: 0.4 nTPM
basophil: 0.3 nTPM
memory CD4 T-cell: 0.3 nTPM

Brain region

choroid plexus: 10 nTPM
midbrain: 7.2 nTPM
medulla oblongata: 5.8 nTPM
white matter: 5.8 nTPM
spinal cord: 5.1 nTPM
hypothalamus: 5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.3
gnomAD pLI: 0
gnomAD missense Z: -0.01
DepMap mean gene effect: -0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

zinc ion binding

Protein domainsUniProt · Pfam · InterPro

Zinc finger, C2HC/C3H-type
Zinc finger C2HC domain-containing protein 1C

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZC2HC1C as an antibody target. Whether an autoantibody or antibody against ZC2HC1C could matter depends on whether native ZC2HC1C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZC2HC1C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZC2HC1C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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