Seroatlas · Human Serome Atlas

ZC2HC1B

Zinc finger C2HC domain-containing protein 1B

Also known as: C6orf94, dJ468K18.5, FAM164B, ZC21B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5TFG8
Gene
ZC2HC1B
Ensembl
ENSG00000118491
Chromosome
6
Canonical length
222 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable zinc ion binding activity. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

222 residues, UniProt reviewed canonical sequence.

>Q5TFG8|ZC2HC1B
     1  MAGAEPFLAD GNQELFPCEV CGRRFAADVL ERHGPICKKL FNRKRKPFSS LKQRLQGTDI
    61  PTVKKTPQSK SPPVRKSNWR QQHEDFINAI RSAKQCMLAI KEGRPLPPPP PPSLNPDYIQ
   121  RPYCMRRFNE SAAERHTNFC KDQSSRRVFN PAQTAAKLAS RAQGRAQMGP KKEPTVTSAV
   181  GALLQNRVLV ATNEVPTKSG LAMDPASGAK LRQGFSKSSK KD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZC2HC1B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.56
Highest tissue expression
15 nTPM

Expression across tissuesHPA

Tissue

  • testis: 15 nTPM
  • skeletal muscle: 0.2 nTPM
  • skin: 0.2 nTPM
  • adipose tissue: 0.1 nTPM
  • appendix: 0.1 nTPM
  • breast: 0.1 nTPM

Single-cell type

  • oligodendrocyte progenitor cells: 8.6 nCPM
  • brain inhibitory neurons: 6.1 nCPM
  • bergmann glia: 5.6 nCPM
  • other brain neurons: 5.4 nCPM
  • brain excitatory neurons: 4.2 nCPM
  • astrocytes: 3.4 nCPM

Immune cell

  • memory B-cell: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • cerebral cortex: 0.5 nTPM
  • white matter: 0.4 nTPM
  • hippocampal formation: 0.3 nTPM
  • hypothalamus: 0.3 nTPM
  • medulla oblongata: 0.3 nTPM
  • pons: 0.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.62
gnomAD pLI
0
gnomAD missense Z
0.47
DepMap mean gene effect
0.02
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZC2HC1B as an antibody target. Whether an autoantibody or antibody against ZC2HC1B could matter depends on whether native ZC2HC1B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZC2HC1B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZC2HC1B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZC2HC1B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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