Seroatlas · Human Serome Atlas

ZBTB8OS

Protein archease

Also known as: ARCH, ARCH_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IWT0
Gene: ZBTB8OS
Ensembl: ENSG00000176261
Chromosome: 1
Canonical length: 167 aa
Protein class: Predicted intracellular proteins
Subcellular location: Plasma membrane
Quaternary structure: Homodimer

OverviewNCBI Gene

Predicted to enable metal ion binding activity. Involved in tRNA splicing, via endonucleolytic cleavage and ligation. Part of tRNA-splicing ligase complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

167 residues, UniProt reviewed canonical sequence.

>Q8IWT0|ZBTB8OS
     1  MAQEEEDVRD YNLTEEQKAI KAKYPPVNRK YEYLDHTADV QLHAWGDTLE EAFEQCAMAM
    61  FGYMTDTGTV EPLQTVEVET QGDDLQSLLF HFLDEWLYKF SADEFFIPRE VKVLSIDQRN
   121  FKLRSIGWGE EFSLSKHPQG TEVKAITYSA MQVYNEENPE VFVIIDI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZBTB8OS can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 42 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 42 nTPM
tonsil: 41 nTPM
lymph node: 35 nTPM
epididymis: 34 nTPM
tongue: 33 nTPM
liver: 32 nTPM

Single-cell type

esophageal apical cells: 198 nCPM
plasma cells: 160 nCPM
sertoli cells: 150 nCPM
choroid plexus epithelial cells: 143 nCPM
esophageal suprabasal cells: 136 nCPM
neutrophils: 130 nCPM

Immune cell

T-reg: 87 nTPM
non-classical monocyte: 80 nTPM
memory B-cell: 74 nTPM
eosinophil: 73 nTPM
intermediate monocyte: 72 nTPM
neutrophil: 67 nTPM

Brain region

cerebellum: 25 nTPM
cerebral cortex: 23 nTPM
hypothalamus: 23 nTPM
white matter: 22 nTPM
thalamus: 20 nTPM
pons: 20 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.5
gnomAD pLI: 0.71
gnomAD missense Z: 0.59
DepMap mean gene effect: -1.23
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

metal ion binding
protein guanylyltransferase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

Archease
Archease domain
Archease domain superfamily
Archease protein family (MTH1598/TM1083)

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZBTB8OS as an antibody target. Whether an autoantibody or antibody against ZBTB8OS could matter depends on whether native ZBTB8OS is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZBTB8OS is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZBTB8OS as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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