Seroatlas · Human Serome Atlas

ZBED2

Zinc finger BED domain-containing protein 2

Also known as: MGC10796, ZBED2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BTP6
Gene: ZBED2
Ensembl: ENSG00000177494
Chromosome: 3
Canonical length: 218 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nuclear bodies,Mitochondria,Cytosol

OverviewNCBI Gene

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of keratinocyte differentiation. Predicted to be located in chromatin. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

218 residues, UniProt reviewed canonical sequence.

>Q9BTP6|ZBED2
     1  MMRREDEEEE GTMMKAKGDL EMKEEEEISE TGELVGPFVS AMPTPMPHNK GTRFSEAWEY
    61  FHLAPARAGH HPNQYATCRL CGRQVSRGPG VNVGTTALWK HLKSMHREEL EKSGHGQAGQ
   121  RQDPRPHGPQ LPTGIEGNWG RLLEQVGTMA LWASQREKEV LRRERAVEWR ERAVEKRERA
   181  LEEVERAILE MKWKVRAEKE ACQREKELPA AVHPFHFV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZBED2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.55
Highest tissue expression: 67 nTPM

Expression across tissuesHPA

Tissue

thyroid gland: 67 nTPM
thymus: 44 nTPM
fallopian tube: 19 nTPM
esophagus: 13 nTPM
tonsil: 12 nTPM
lung: 9.8 nTPM

Single-cell type

esophageal apical cells: 156 nCPM
alveolar cells type 1: 61 nCPM
fallopian tube ciliated cells: 48 nCPM
medullary thymic epithelial cells: 41 nCPM
suprabasal keratinocytes: 24 nCPM
esophageal basal cells: 12 nCPM

Immune cell

naive B-cell: 2.1 nTPM
memory B-cell: 1.2 nTPM
naive CD8 T-cell: 0.8 nTPM
naive CD4 T-cell: 0.6 nTPM
T-reg: 0.5 nTPM
gdT-cell: 0.4 nTPM

Brain region

basal ganglia: 1 nTPM
medulla oblongata: 0.2 nTPM
cerebral cortex: 0.1 nTPM
spinal cord: 0.1 nTPM
thalamus: 0.1 nTPM
white matter: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.78
gnomAD pLI: 0
gnomAD missense Z: -0.1
DepMap mean gene effect: 0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZBED2 as an antibody target. Whether an autoantibody or antibody against ZBED2 could matter depends on whether native ZBED2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZBED2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZBED2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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