Seroatlas · Human Serome Atlas

ZBBX

Zinc finger B-box domain-containing protein 1

Also known as: FLJ23049, ZBBX_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A8MT70
Gene: ZBBX
Ensembl: ENSG00000169064
Chromosome: 3
Canonical length: 800 aa
Protein class: Predicted intracellular proteins
Subcellular location: Golgi apparatus

OverviewNCBI Gene

Predicted to enable zinc ion binding activity. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

800 residues, UniProt reviewed canonical sequence.

>A8MT70|ZBBX
     1  MNRKDFVVLP WGKPGNSVKL KYRNAQELRM EKVQLEFENQ EMEKKLQEFR STRNKEKEDR
    61  ESSEYYWKSG KVGKLVNQSY MMSQNKGNVV KFSAGKVKLK LLKEQIQEPV KPTVNYKMAN
   121  SSECEKPKIN GKVCGQCENK AALLVCLECG EDYCSGCFAK VHQKGALKLH RTTLLQAKSQ
   181  ILFNVLDVAH QFIKDVNPDE PKEENNSTKE TSKIQHKPKS VLLQRSSSEV EITTMKRAQR
   241  TKPRKSLLCE GSFDEEASAQ SFQEVLSQWR TGNHDDNKKQ NLHAAVKDSL EECEVQTNLK
   301  IWREPLNIEL KEDILSYMEK LWLKKHRRTP QEQLFKMLPD TFPHPHETTG DAQCSQNEND
   361  EDSDGEETKV QHTALLLPVE TLNIERPEPS LKIVELDDTY EEEFEEAENI VPYKVKLADA
   421  DSQRSCAFHD CQKNSFPYEN GIHQHHVFDK GKRDFLNLCL RNSSTYYKDN SKAETSNTDF
   481  DNIVDPDVYS SDIEKIEEST SFERNLKEKN IGLESNQKSD DSCVSLESKD TLLGRDLEKA
   541  PIEEKLSQDI KESLELSNLY KRPSFEESKT TKSSLLLQEI ACRSKPITKQ YQGLERFFIF
   601  DTNERLNLLP SHRLECNNSS TRITLAGQKS QRPSTANFPL SNSVKESSSC LSSSHPRSRS
   661  AAAQSSSRAA SEISEIEYID ITDQNELSLD DTTDQHTLDN LEKELQVLRS LADTSEKLYS
   721  LTSEEFPDFS SQSLNISQIS TDFLKTSHVR GPCGVEELSC SGRDTKIQSL LSLSESSTDE
   781  EEEDFLNKQH VITLPWSKST

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZBBX can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.65
Highest tissue expression: 34 nTPM

Expression across tissuesHPA

Tissue

testis: 34 nTPM
fallopian tube: 22 nTPM
choroid plexus: 13 nTPM
lung: 3.3 nTPM
hypothalamus: 2.5 nTPM
cerebral cortex: 2.3 nTPM

Single-cell type

ependymal cells: 1,090 nCPM
respiratory ciliated cells: 717 nCPM
early spermatids: 431 nCPM
fallopian tube ciliated cells: 396 nCPM
choroid plexus epithelial cells: 393 nCPM
late spermatids: 356 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 64 nTPM
medulla oblongata: 32 nTPM
midbrain: 26 nTPM
spinal cord: 25 nTPM
white matter: 15 nTPM
amygdala: 10 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.06
gnomAD pLI: 0
gnomAD missense Z: 0.13
DepMap mean gene effect: 0.11
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

zinc ion binding

Protein domainsUniProt · Pfam · InterPro

ANCHR-like B-box zinc-binding domain
Zinc finger B-box domain-containing protein

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZBBX as an antibody target. Whether an autoantibody or antibody against ZBBX could matter depends on whether native ZBBX is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZBBX is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZBBX as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...