Seroatlas · Human Serome Atlas

YWHAH-AS1

Putative uncharacterized protein YWHAH-AS1

Also known as: CV024_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y442
Gene: YWHAH-AS1
Canonical length: 160 aa

OverviewNCBI Gene

No narrative summary is available for YWHAH-AS1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

160 residues, UniProt reviewed canonical sequence.

>Q9Y442|YWHAH-AS1
     1  MTTQEDTTGL HQKTSLWTMS RPGAKKVMNS YFIAGCGPAV CYYAVSWLRQ GFSINLTSFG
    61  RIPWPHAGVG TCPSPQSWIS PFLQSHREHH YAKTSSHSQP SPQSLALCLA YSRCSINICQ
   121  MTECISLASG CHQALREPGR SEESFWIPAT PYISNIFSES

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against YWHAH-AS1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.62

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

membrane

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads YWHAH-AS1 as an antibody target. Whether an autoantibody or antibody against YWHAH-AS1 could matter depends on whether native YWHAH-AS1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

YWHAH-AS1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label YWHAH-AS1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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