Seroatlas · Human Serome Atlas

YJEFN3

YjeF N-terminal domain-containing protein 3

Also known as: FLJ44968, hYjeF_N3-19p13.11, YJEN3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6XGL0
Gene: YJEFN3
Ensembl: ENSG00000250067
Chromosome: 19
Canonical length: 299 aa
Protein class: Predicted intracellular proteins
Subcellular location: Mitochondria

OverviewNCBI Gene

Predicted to enable NAD(P)HX epimerase activity. Predicted to be involved in several processes, including hematopoietic stem cell proliferation; membrane raft distribution; and negative regulation of angiogenesis. Predicted to be active in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

299 residues, UniProt reviewed canonical sequence.

>A6XGL0|YJEFN3
     1  MSSAAGPDPS EAPEERHFLR ALELQPPLAD MGRAELSSNA TTSLVQRRKQ AWGRQSWLEQ
    61  IWNAGPVCQS TAEAAALERE LLEDYRFGRQ QLVELCGHAS AVAVTKAFPL PALSRKQRTV
   121  LVVCGPEQNG AVGLVCARHL RVFEYEPTIF YPTRSLDLLH RDLTTQCEKM DIPFLSYLPT
   181  EVQLINEAYG LVVDAVLGPG VEPGEVGGPC TRALATLKLL SIPLVSLDIP SGWDAETGSD
   241  SEDGLRPDVL VSLAAPKRCA GRFSGRHHFV AGRFVPDDVR RKFALRLPGY TGTDCVAAL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against YJEFN3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 203 nTPM

Expression across tissuesHPA

Tissue

basal ganglia: 203 nTPM
hippocampal formation: 146 nTPM
amygdala: 108 nTPM
cerebral cortex: 97 nTPM
hypothalamus: 41 nTPM
midbrain: 32 nTPM

Single-cell type

late spermatids: 977 nCPM
early spermatids: 158 nCPM
epididymal principal cells: 127 nCPM
brain inhibitory neurons: 49 nCPM
late primary spermatocytes: 34 nCPM
brain excitatory neurons: 33 nCPM

Immune cell

T-reg: 0.4 nTPM
intermediate monocyte: 0.2 nTPM
memory CD4 T-cell: 0.2 nTPM
classical monocyte: 0.1 nTPM
gdT-cell: 0.1 nTPM
MAIT T-cell: 0.1 nTPM

Brain region

hippocampal formation: 123 nTPM
basal ganglia: 112 nTPM
cerebral cortex: 92 nTPM
amygdala: 63 nTPM
hypothalamus: 49 nTPM
white matter: 35 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.27
gnomAD pLI: 0
gnomAD missense Z: -0.12
DepMap mean gene effect: -0.2
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

NAD(P)HX epimerase activity

Cellular components

mitochondrion

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of YJEFN3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

APOA1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads YJEFN3 as an antibody target. Whether an autoantibody or antibody against YJEFN3 could matter depends on whether native YJEFN3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

YJEFN3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label YJEFN3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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