Seroatlas · Human Serome Atlas

YIPF7

Protein YIPF7

Also known as: FinGER9, FLJ39576, YIPF7_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N8F6
Gene: YIPF7
Ensembl: ENSG00000177752
Chromosome: 4
Canonical length: 256 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport and vesicle fusion with Golgi apparatus. Predicted to act upstream of or within Golgi organization. Predicted to be located in cis-Golgi network; endoplasmic reticulum membrane; and endoplasmic reticulum-Golgi intermediate compartment. Predicted to be active in trans-Golgi network. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

256 residues, UniProt reviewed canonical sequence.

>Q8N8F6|YIPF7
     1  MSNLAQFDSD FYQSNFTIDN QEQSGNDSNA YGNLYGSRKQ QAGEQPQPAS FVPSEMLMSS
    61  GYAGQFFQPA SNSDYYSQSP YIDSFDEEPP LLEELGIHFD HIWQKTLTVL NPMKPVDGSI
   121  MNETDLTGPI LFCVALGATL LLAGKVQFGY VYGMSAIGCL VIHALLNLMS SSGVSYGCVA
   181  SVLGYCLLPM VILSGCAMFF SLQGIFGIMS SLVIIGWCSL SASKIFIAAL HMEGQQLLVA
   241  YPCAILYGLF ALLTIF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against YIPF7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 5
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 65 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 65 nTPM
tongue: 20 nTPM
cerebellum: 0.8 nTPM
basal ganglia: 0.5 nTPM
choroid plexus: 0.5 nTPM
heart muscle: 0.5 nTPM

Single-cell type

myonuclei: 114 nCPM
brain excitatory neurons: 17 nCPM
cardiomyocytes: 15 nCPM
brain inhibitory neurons: 14 nCPM
retinal amacrine cells: 13 nCPM
other brain neurons: 12 nCPM

Immune cell

plasmacytoid DC: 1 nTPM
memory B-cell: 0.6 nTPM
classical monocyte: 0.4 nTPM
eosinophil: 0.3 nTPM
memory CD8 T-cell: 0.3 nTPM
naive B-cell: 0.2 nTPM

Brain region

cerebellum: 15 nTPM
cerebral cortex: 4.4 nTPM
hypothalamus: 4.4 nTPM
hippocampal formation: 3.8 nTPM
white matter: 3.8 nTPM
midbrain: 3.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.35
gnomAD pLI: 0
gnomAD missense Z: -0.4
DepMap mean gene effect: 0
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads YIPF7 as an antibody target. Whether an autoantibody or antibody against YIPF7 could matter depends on whether native YIPF7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

YIPF7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label YIPF7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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