YBEY
Endoribonuclease YbeY
Also known as: C21orf57, YBEY_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P58557
- Gene
- YBEY
- Ensembl
- ENSG00000182362
- Chromosome
- 21
- Canonical length
- 167 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm
OverviewNCBI Gene
This gene encodes a highly conserved metalloprotein. A similar protein in bacteria acts as an endoribonuclease, and is thought to function in ribosomal RNA maturation and ribosome assembly. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Canonical amino-acid sequenceUniProt
167 residues, UniProt reviewed canonical sequence.
>P58557|YBEY
1 MSLVIRNLQR VIPIRRAPLR SKIEIVRRIL GVQKFDLGII CVDNKNIQHI NRIYRDRNVP
61 TDVLSFPFHE HLKAGEFPQP DFPDDYNLGD IFLGVEYIFH QCKENEDYND VLTVTATHGL
121 CHLLGFTHGT EAEWQQMFQK EKAVLDELGR RTGTRLQPLT RGLFGGSLocalizationUniProt · AlphaFold · HPA
Whether an antibody against YBEY can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.28
- Highest tissue expression
- 75 nTPM
Expression across tissuesHPA
Tissue
- testis: 75 nTPM
- spinal cord: 25 nTPM
- midbrain: 19 nTPM
- liver: 18 nTPM
- pancreas: 16 nTPM
- heart muscle: 16 nTPM
Single-cell type
- late primary spermatocytes: 725 nCPM
- late spermatids: 355 nCPM
- early spermatids: 315 nCPM
- enterocytes: 100 nCPM
- early primary spermatocytes: 88 nCPM
- epididymal principal cells: 81 nCPM
Immune cell
- memory B-cell: 33 nTPM
- basophil: 28 nTPM
- T-reg: 27 nTPM
- naive B-cell: 25 nTPM
- plasmacytoid DC: 24 nTPM
- NK-cell: 21 nTPM
Brain region
- white matter: 14 nTPM
- cerebellum: 11 nTPM
- pons: 11 nTPM
- medulla oblongata: 11 nTPM
- basal ganglia: 10 nTPM
- spinal cord: 9.9 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.92
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.01
- DepMap mean gene effect
- -0.06
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Endoribonuclease YbeY
- Endoribonuclease YbeY, conserved site
- Metalloprotease catalytic domain superfamily, predicted
- Endoribonuclease YbeY
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads YBEY as an antibody target. Whether an autoantibody or antibody against YBEY could matter depends on whether native YBEY is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
YBEY is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label YBEY as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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