Seroatlas · Human Serome Atlas

XRRA1

X-ray radiation resistance-associated protein 1

Also known as: FLJ00225, XRRA1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6P2D8
Gene: XRRA1
Ensembl: ENSG00000166435
Chromosome: 11
Canonical length: 792 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear bodies

OverviewNCBI Gene

Involved in response to X-ray. Located in cytoplasm and nuclear body. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

792 residues, UniProt reviewed canonical sequence.

>Q6P2D8|XRRA1
     1  MAFSGIYKLD DGKPYLNNCF PARNLLRVPE EGQGHWLVVQ KGNLKKKPKG LVGAQAERRE
    61  SLKATSFEFK GKKESRRENQ VDLPGHILDQ AFLLKHHCVR KPSDLCTINA KENDFKHFHS
   121  VIYINASENL LPLEAFHTFP ALKELDLAFN GIKTIYVKYG DFKLLEFLDL SFNSLTVEAI
   181  CDLGILPHLR VLLLTGNGLT SLPPNLAVAE QEASVTSLTS KRYILRFPAL ETLMLDDNRL
   241  SNPSCFASLA GLRRLKKLSL DENRIIRIPY LQQVQLYDES VDWNGGRGSP HKEPQFMLQS
   301  KPRMLEDSDE QLDYTVLPMK KDVDRTEVVF SSYPGFSTSE TTKICSLPPI FEILPVKSLK
   361  ARNQTLAPPF PELRYLSLAY NKIAKEDAVL PVALFPSLCE FVFHNNPLVA HTRGVPPLLK
   421  SFLQERLGIH LIRRKIVKPK HHVLMSRKES WKVKSEIPKV PKQPLVLHHP RMTTTKSPSK
   481  DMLEPEAELA EDLPTTKSTS VESEMPTENL EGHSPSCRTF VPLPPICSNS TVHSEETLSH
   541  LSDTTVRLSP ERPSDEDSKS TESIFLTQVS ELPSSVIHKD DLELKEKDQK KPPTAPREVK
   601  GTRRKLPTAF LPSKYHGYEE LLTAKPDPAF IEPKGIQKNA QALQQMLKHP LLCHSSKPKL
   661  DTLQKPYVHK EKRAQRIPIP PPKKTRAQLL DDIFIRLRDP RNITEAPLGA VLHQWTERRL
   721  VNHKQYLEAK RLLKEFQARY RQLVSGSLRT VFGTTPLPMA CPALSESQPK FGHFLEFMDE
   781  FCQEPTASDS QG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against XRRA1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.52
Highest tissue expression: 17 nTPM

Expression across tissuesHPA

Tissue

testis: 17 nTPM
tongue: 11 nTPM
thyroid gland: 6.4 nTPM
skeletal muscle: 5.3 nTPM
salivary gland: 5 nTPM
ovary: 4.7 nTPM

Single-cell type

epicardial cells: 500 nCPM
cardiomyocytes: 260 nCPM
myonuclei: 238 nCPM
choroid plexus epithelial cells: 209 nCPM
cone photoreceptor cells: 199 nCPM
oligodendrocytes: 188 nCPM

Immune cell

T-reg: 4.4 nTPM
neutrophil: 3.3 nTPM
MAIT T-cell: 3.2 nTPM
gdT-cell: 2.9 nTPM
intermediate monocyte: 2.5 nTPM
memory CD4 T-cell: 2.1 nTPM

Brain region

white matter: 12 nTPM
thalamus: 11 nTPM
basal ganglia: 9.5 nTPM
medulla oblongata: 9.2 nTPM
pons: 9.2 nTPM
hypothalamus: 9.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.78
gnomAD pLI: 0
gnomAD missense Z: -0.03
DepMap mean gene effect: -0.16
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

response to X-ray

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads XRRA1 as an antibody target. Whether an autoantibody or antibody against XRRA1 could matter depends on whether native XRRA1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

XRRA1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label XRRA1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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