Seroatlas · Human Serome Atlas

XKRY

Testis-specific XK-related protein, Y-linked

Also known as: XKRY_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O14609
Gene: XKRY
Canonical length: 159 aa

OverviewNCBI Gene

No narrative summary is available for XKRY in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

159 residues, UniProt reviewed canonical sequence.

>O14609|XKRY
     1  MFIFNSIADD IFPLISCVGA IHCNILAIRT GNDFAAIKLQ VIKLIYLMIW HSLVIISPVV
    61  TLAFFPASLK QGSLHFLLII YFVLLLTPWL EFSKSGTHLP SNTKIIPAWW VSMDAYLNHA
   121  SICCHQFSCL SAVKLQLSNE ELIRDTRWDI QSYTTDFSF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against XKRY can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 3
Mean surface accessibility (rSASA): 0.5

OntologyGO

Biological processes

single fertilization

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

XK-related membrane adapter

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads XKRY as an antibody target. Whether an autoantibody or antibody against XKRY could matter depends on whether native XKRY is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

XKRY is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label XKRY as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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