Seroatlas · Human Serome Atlas

XKR7

XK-related protein 7

Also known as: C20orf159, dJ310O13.4, XKR7_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5GH72
Gene: XKR7
Ensembl: ENSG00000260903
Chromosome: 20
Canonical length: 579 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

Predicted to be involved in apoptotic process involved in development; engulfment of apoptotic cell; and phosphatidylserine exposure on apoptotic cell surface. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

579 residues, UniProt reviewed canonical sequence.

>Q5GH72|XKR7
     1  MAAKSDGAAA SASPDPEGAA GGARGSAGGR GEAAAAAGPP GVVGAGGPGP RYELRDCCWV
    61  LCALLVFFSD GATDLWLAAS YYLQNQHTYF SLTLLFVLLP SLVVQLLSFR WFVYDYSEPA
   121  GSPGPAVSTK DSVAGGAAIS TKDSAGAFRT KEGSPEPGPQ PAPSSASAYR RRCCRLCIWL
   181  LQTLVHLLQL GQVWRYLRAL YLGLQSRWRG ERLRRHFYWQ MLFESADVSM LRLLETFLRS
   241  APQLVLQLSL LVHRGGAPDL LPALSTSASL VSLAWTLASY QKVLRDSRDD KRPLSYKGAV
   301  AQVLWHLFSI AARGLAFALF ASVYKLYFGI FIVAHWCVMT FWVIQGETDF CMSKWEEIIY
   361  NMVVGIIYIF CWFNVKEGRS RRRMTLYHCI VLLENAALTG FWYSSRNFST DFYSLIMVCV
   421  VASSFALGIF FMCVYYCLLH PNGPMLGPQA PGCIFRKASE PCGPPADAIT SPPRSLPRTT
   481  GAERDGASAG ERAGTPTPPV FQVRPGLPPT PVARTLRTEG PVIRIDLPRK KYPAWDAHFI
   541  DRRLRKTILA LEYSSPATPR LQYRSVGTSQ ELLEYETTV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against XKR7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 15 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 15 nTPM
retina: 4.4 nTPM
pituitary gland: 4.1 nTPM
cerebral cortex: 2 nTPM
hypothalamus: 0.8 nTPM
amygdala: 0.5 nTPM

Single-cell type

retinal bipolar cells: 20 nCPM
thyrotrophs: 19 nCPM
lactotrophs: 18 nCPM
brain excitatory neurons: 16 nCPM
cone photoreceptor cells: 15 nCPM
rod photoreceptor cells: 14 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 21 nTPM
cerebral cortex: 10 nTPM
white matter: 6.2 nTPM
basal ganglia: 5.4 nTPM
hypothalamus: 4.2 nTPM
amygdala: 4 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about XKR7.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 89 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Moyamoya angiopathy

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.38
gnomAD pLI: 0.91
gnomAD missense Z: 1.57
DepMap mean gene effect: -0.17
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads XKR7 as an antibody target. Whether an autoantibody or antibody against XKR7 could matter depends on whether native XKR7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

XKR7 is annotated at the cell surface, where native XKR7 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label XKR7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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