Seroatlas · Human Serome Atlas

XKR5

XK-related protein 5

Also known as: XKR5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6UX68
Gene: XKR5
Ensembl: ENSG00000275591
Chromosome: 8
Canonical length: 686 aa
Protein class: Predicted membrane proteins, Transporters

OverviewNCBI Gene

Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

686 residues, UniProt reviewed canonical sequence.

>Q6UX68|XKR5
     1  MHARLLGLSA LLQAAEQSAR LYTVAYYFTT GRLLWGWLAL AVLLPGFLVQ ALSYLWFRAD
    61  GHPGHCSLMM LHLLQLGVWK RHWDAALTSL QKELEAPHRG WLQLQEADLS ALRLLEALLQ
   121  TGPHLLLQTY VFLASDFTDI VPGVSTLFSW SSLSWALVSY TRFMGFMKPG HLAMPWAALF
   181  CQQLWRMGML GTRVLSLVLF YKAYHFWVFV VAGAHWLVMT FWLVAQQSDI IDSTCHWRLF
   241  NLLVGAVYIL CYLSFWDSPS RNRMVTFYMV MLLENIILLL LATDFLQGAS WTSLQTIAGV
   301  LSGFLIGSVS LVIYYSLLHP KSTDIWQGCL RKSCGIAGGD KTERRDSPRA TDLAGKRTES
   361  SGSCQGASYE PTILGKPPTP EQVPPEAGLG TQVAVEDSFL SHHHWLWVKL ALKTGNVSKI
   421  NAAFGDNSPA YCPPAWGLSQ QDYLQRKALS AQQELPSSSR DPSTLENSSA FEGVPKAEAD
   481  PLETSSYVSF ASDQQDEAPT QNPAATQGEG TPKEGADAVS GTQGKGTGGQ QRGGEGQQSS
   541  TLYFSATAEV ATSSQQEGSP ATLQTAHSGR RLGKSSPAQP ASPHPVGLAP FPDTMADISP
   601  ILGTGPCRGF CPSAGFPGRT LSISELEEPL EPKRELSHHA AVGVWVSLPQ LRTAHEPCLT
   661  STPKSESIQT DCSCREQMKQ EPSFFI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against XKR5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 5
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 0.6 nTPM

Expression across tissuesHPA

Tissue

cervix: 0.6 nTPM
bone marrow: 0.4 nTPM
endometrium: 0.4 nTPM
fallopian tube: 0.4 nTPM
prostate: 0.4 nTPM
smooth muscle: 0.4 nTPM

Single-cell type

neutrophils: 3.7 nCPM
neutrophil progenitors: 2.2 nCPM
lacrimal acinar cells: 0.9 nCPM
monocyte progenitors: 0.8 nCPM
salivary ionocytes: 0.7 nCPM
megakaryocyte progenitors: 0.5 nCPM

Immune cell

basophil: 0.4 nTPM
neutrophil: 0.2 nTPM
naive B-cell: 0.1 nTPM
plasmacytoid DC: 0.1 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM

Brain region

cerebellum: 1.9 nTPM
white matter: 1.9 nTPM
cerebral cortex: 1.7 nTPM
choroid plexus: 1.7 nTPM
hippocampal formation: 1.6 nTPM
medulla oblongata: 1.6 nTPM

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads XKR5 as an antibody target. Whether an autoantibody or antibody against XKR5 could matter depends on whether native XKR5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

XKR5 is annotated at the cell surface, where native XKR5 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label XKR5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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