Seroatlas · Human Serome Atlas

XCR1

Chemokine XC receptor 1

Also known as: CCXCR1, GPR5, XCR1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P46094
Gene
XCR1
Ensembl
ENSG00000173578
Chromosome
3
Canonical length
333 aa
Protein class
G-protein coupled receptors, Human disease related genes, Predicted membrane proteins

OverviewNCBI Gene

The protein encoded by this gene is a chemokine receptor belonging to the G protein-coupled receptor superfamily. The family members are characterized by the presence of 7 transmembrane domains. The encoded protein transduces a signal by increasing the intracellular calcium ion level. The viral macrophage inflammatory protein-II is an antagonist of this receptor and blocks signaling. Some studies have implicated a cluster of genes at 3p21.31, including this gene, as associated with COVID-19 risk. The encoded protein may also play a role in cell proliferation and migration in several types of cancer. [provided by RefSeq, Jan 2023]

Canonical amino-acid sequenceUniProt

333 residues, UniProt reviewed canonical sequence.

>P46094|XCR1
     1  MESSGNPEST TFFYYDLQSQ PCENQAWVFA TLATTVLYCL VFLLSLVGNS LVLWVLVKYE
    61  SLESLTNIFI LNLCLSDLVF ACLLPVWISP YHWGWVLGDF LCKLLNMIFS ISLYSSIFFL
   121  TIMTIHRYLS VVSPLSTLRV PTLRCRVLVT MAVWVASILS SILDTIFHKV LSSGCDYSEL
   181  TWYLTSVYQH NLFFLLSLGI ILFCYVEILR TLFRSRSKRR HRTVKLIFAI VVAYFLSWGP
   241  YNFTLFLQTL FRTQIIRSCE AKQQLEYALL ICRNLAFSHC CFNPVLYVFV GVKFRTHLKH
   301  VLRQFWFCRL QAPSPASIPH SPGAFAYEGA SFY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against XCR1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
8.2 nTPM

Expression across tissuesHPA

Tissue

  • lymph node: 8.2 nTPM
  • thymus: 5.7 nTPM
  • spleen: 5.1 nTPM
  • tonsil: 3.5 nTPM
  • placenta: 2.7 nTPM
  • appendix: 2.5 nTPM

Single-cell type

  • myonuclei: 237 nCPM
  • cdc: 30 nCPM
  • extravillous trophoblasts: 25 nCPM
  • migrating cytotrophoblasts: 23 nCPM
  • pdcs: 17 nCPM
  • plasma cells: 7.3 nCPM

Immune cell

  • myeloid DC: 2.3 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • thalamus: 0.6 nTPM
  • cerebral cortex: 0.2 nTPM
  • medulla oblongata: 0.2 nTPM
  • midbrain: 0.2 nTPM
  • amygdala: 0.1 nTPM
  • basal ganglia: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.08
gnomAD pLI
0.02
gnomAD missense Z
1.12
DepMap mean gene effect
0.04
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads XCR1 as an antibody target. Whether an autoantibody or antibody against XCR1 could matter depends on whether native XCR1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

XCR1 is annotated at the cell surface, where native XCR1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label XCR1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/XCR1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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