Seroatlas · Human Serome Atlas

XCL2

Cytokine SCM-1 beta

Also known as: SCM-1b, SCYC2, XCL2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UBD3
Gene: XCL2
Ensembl: ENSG00000143185
Chromosome: 1
Canonical length: 114 aa
Protein class: Predicted secreted proteins
Secretome location: Secreted to blood

OverviewNCBI Gene

Predicted to enable CCR chemokine receptor binding activity and chemokine activity. Predicted to be involved in several processes, including antimicrobial humoral immune response mediated by antimicrobial peptide; cell chemotaxis; and chemokine-mediated signaling pathway. Predicted to be located in extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

114 residues, UniProt reviewed canonical sequence.

>Q9UBD3|XCL2
     1  MRLLILALLG ICSLTAYIVE GVGSEVSHRR TCVSLTTQRL PVSRIKTYTI TEGSLRAVIF
    61  ITKRGLKVCA DPQATWVRDV VRSMDRKSNT RNNMIQTKPT GTQQSTNTAV TLTG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against XCL2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 13 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 13 nTPM
spleen: 13 nTPM
liver: 5.2 nTPM
lymph node: 5.2 nTPM
thymus: 3.6 nTPM
endometrium: 3.4 nTPM

Single-cell type

nk-cells: 322 nCPM
innate lymphoid cells: 208 nCPM
t-cells: 142 nCPM
pdcs: 25 nCPM
endometrial secretory cells: 11 nCPM
thymocytes: 7.6 nCPM

Immune cell

NK-cell: 424 nTPM
memory CD8 T-cell: 50 nTPM
gdT-cell: 47 nTPM
naive CD8 T-cell: 37 nTPM
total PBMC: 17 nTPM
memory CD4 T-cell: 3.6 nTPM

Brain region

hypothalamus: 0.7 nTPM
medulla oblongata: 0.5 nTPM
pons: 0.4 nTPM
spinal cord: 0.3 nTPM
thalamus: 0.3 nTPM
white matter: 0.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.79
gnomAD pLI: 0.01
gnomAD missense Z: -0.32
DepMap mean gene effect: -0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads XCL2 as an antibody target. Whether an autoantibody or antibody against XCL2 could matter depends on whether native XCL2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

XCL2 is annotated as secreted, so native XCL2 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Source-annotated serology context

The source annotations explicitly mention antibody, autoantibody, autoantigen, or autoimmune context. This is biological context, not study-specific reactivity.

Predicted to be involved in several processes, including antimicrobial humoral immune response mediated by antimicrobial peptide; cell chemotaxis; and chemokine-mediated signaling pathway.

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