XAGE5
X antigen family member 5
Also known as: CT12.5, GAGED5, XAGE-5, XAGE5_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8WWM1
- Gene
- XAGE5
- Ensembl
- ENSG00000171405
- Chromosome
- X
- Canonical length
- 108 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Vesicles
OverviewNCBI Gene
This gene is a member of the XAGE subfamily, which belongs to the GAGE family. The GAGE genes are expressed in a variety of tumors and in some fetal and reproductive tissues. The protein encoded by this gene shares a sequence similarity with other GAGE/PAGE proteins. Because of the expression pattern and the sequence similarity, this protein also belongs to a family of CT (cancer-testis) antigens. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
108 residues, UniProt reviewed canonical sequence.
>Q8WWM1|XAGE5
1 MSWRGRRYRP RRCLRLAQLV GPMLEPSVPE PQQEEPPTES QDHTPGQKRE DDQGAAEIQV
61 PNLEADLQEL SQSKTGDECG DSPDVQGKIL PKSEQFKMPE GGEGKPQLLocalizationUniProt · AlphaFold · HPA
Whether an antibody against XAGE5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.68
- Highest tissue expression
- 1.1 nTPM
Expression across tissuesHPA
Tissue
- testis: 1.1 nTPM
- adipose tissue: 0 nTPM
- adrenal gland: 0 nTPM
- amygdala: 0 nTPM
- appendix: 0 nTPM
- basal ganglia: 0 nTPM
Single-cell type
- differentiating spermatogonia: 16 nCPM
- early primary spermatocytes: 9.8 nCPM
- undifferentiated spermatogonia: 9.2 nCPM
- schwann cells: 1.8 nCPM
- syncytiotrophoblasts: 1.4 nCPM
- adrenal cortex cells: 0.4 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- medulla oblongata: 0.1 nTPM
- amygdala: 0 nTPM
- basal ganglia: 0 nTPM
- cerebellum: 0 nTPM
- cerebral cortex: 0 nTPM
- choroid plexus: 0 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.87
- gnomAD pLI
- 0
- gnomAD missense Z
- -1.14
- DepMap mean gene effect
- -0.05
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Protein domainsUniProt · Pfam · InterPro
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads XAGE5 as an antibody target. Whether an autoantibody or antibody against XAGE5 could matter depends on whether native XAGE5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
XAGE5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label XAGE5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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