Seroatlas · Human Serome Atlas

WNT8A

Protein Wnt-8a

Also known as: WNT8A_HUMAN, WNT8D

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H1J5
Gene: WNT8A
Ensembl: ENSG00000061492
Chromosome: 5
Canonical length: 351 aa
Protein class: Predicted secreted proteins
Secretome location: Secreted to extracellular matrix

OverviewNCBI Gene

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family, and may be implicated in development of early embryos as well as germ cell tumors. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2014]

Canonical amino-acid sequenceUniProt

351 residues, UniProt reviewed canonical sequence.

>Q9H1J5|WNT8A
     1  MGNLFMLWAA LGICCAAFSA SAWSVNNFLI TGPKAYLTYT TSVALGAQSG IEECKFQFAW
    61  ERWNCPENAL QLSTHNRLRS ATRETSFIHA ISSAGVMYII TKNCSMGDFE NCGCDGSNNG
   121  KTGGHGWIWG GCSDNVEFGE RISKLFVDSL EKGKDARALM NLHNNRAGRL AVRATMKRTC
   181  KCHGISGSCS IQTCWLQLAE FREMGDYLKA KYDQALKIEM DKRQLRAGNS AEGHWVPAEA
   241  FLPSAEAELI FLEESPDYCT CNSSLGIYGT EGRECLQNSH NTSRWERRSC GRLCTECGLQ
   301  VEERKTEVIS SCNCKFQWCC TVKCDQCRHV VSKYYCARSP GSAQSLGKGS A

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against WNT8A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 0.6 nTPM

Expression across tissuesHPA

Tissue

testis: 0.6 nTPM
basal ganglia: 0.4 nTPM
cerebral cortex: 0.2 nTPM
cerebellum: 0.1 nTPM
hippocampal formation: 0.1 nTPM
adipose tissue: 0 nTPM

Single-cell type

brain inhibitory neurons: 3.4 nCPM
ependymal cells: 3 nCPM
brain excitatory neurons: 2.6 nCPM
retinal amacrine cells: 2.1 nCPM
early primary spermatocytes: 1.3 nCPM
other brain neurons: 1.3 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 2.7 nTPM
basal ganglia: 2.4 nTPM
white matter: 2.4 nTPM
hippocampal formation: 2 nTPM
amygdala: 1.6 nTPM
medulla oblongata: 1.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.75
gnomAD pLI: 0.01
gnomAD missense Z: 1.13
DepMap mean gene effect: -0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads WNT8A as an antibody target. Whether an autoantibody or antibody against WNT8A could matter depends on whether native WNT8A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

WNT8A is annotated as secreted, so native WNT8A circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label WNT8A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...