Seroatlas · Human Serome Atlas

WNT5B

Protein Wnt-5b

Also known as: WNT5B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9H1J7
Gene
WNT5B
Ensembl
ENSG00000111186
Chromosome
12
Canonical length
359 aa
Protein class
Predicted secreted proteins
Subcellular location
Vesicles
Secretome location
Secreted to extracellular matrix

OverviewNCBI Gene

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 94% and 80% amino acid identity to the mouse Wnt5b protein and the human WNT5A protein, respectively. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

359 residues, UniProt reviewed canonical sequence.

>Q9H1J7|WNT5B
     1  MPSLLLLFTA ALLSSWAQLL TDANSWWSLA LNPVQRPEMF IIGAQPVCSQ LPGLSPGQRK
    61  LCQLYQEHMA YIGEGAKTGI KECQHQFRQR RWNCSTADNA SVFGRVMQIG SRETAFTHAV
   121  SAAGVVNAIS RACREGELST CGCSRTARPK DLPRDWLWGG CGDNVEYGYR FAKEFVDARE
   181  REKNFAKGSE EQGRVLMNLQ NNEAGRRAVY KMADVACKCH GVSGSCSLKT CWLQLAEFRK
   241  VGDRLKEKYD SAAAMRVTRK GRLELVNSRF TQPTPEDLVY VDPSPDYCLR NESTGSLGTQ
   301  GRLCNKTSEG MDGCELMCCG RGYNQFKSVQ VERCHCKFHW CCFVRCKKCT EIVDQYICK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against WNT5B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
32 nTPM

Expression across tissuesHPA

Tissue

  • prostate: 32 nTPM
  • colon: 25 nTPM
  • seminal vesicle: 19 nTPM
  • urinary bladder: 16 nTPM
  • salivary gland: 15 nTPM
  • esophagus: 14 nTPM

Single-cell type

  • prostatic club cells: 311 nCPM
  • prostatic glandular cells: 269 nCPM
  • müller glia: 231 nCPM
  • basal prostatic cells: 217 nCPM
  • prostatic hillock cells: 193 nCPM
  • plasma cells: 158 nCPM

Immune cell

  • classical monocyte: 1.8 nTPM
  • eosinophil: 1.5 nTPM
  • myeloid DC: 0.9 nTPM
  • intermediate monocyte: 0.8 nTPM
  • total PBMC: 0.5 nTPM
  • neutrophil: 0.1 nTPM

Brain region

  • hypothalamus: 8.9 nTPM
  • medulla oblongata: 7.5 nTPM
  • pons: 7.5 nTPM
  • thalamus: 6.7 nTPM
  • basal ganglia: 6.4 nTPM
  • spinal cord: 6.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.49
gnomAD pLI
0.59
gnomAD missense Z
1.79
DepMap mean gene effect
-0.1
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of WNT5B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads WNT5B as an antibody target. Whether an autoantibody or antibody against WNT5B could matter depends on whether native WNT5B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

WNT5B is annotated as secreted, so native WNT5B circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label WNT5B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/WNT5B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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