Seroatlas · Human Serome Atlas

WNT11

Protein Wnt-11

Also known as: WNT11_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O96014
Gene
WNT11
Ensembl
ENSG00000085741
Chromosome
11
Canonical length
354 aa
Protein class
Predicted intracellular proteins, Predicted secreted proteins
Secretome location
Secreted to extracellular matrix

OverviewNCBI Gene

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 97%, 85%, and 63% amino acid identity with mouse, chicken, and Xenopus Wnt11 protein, respectively. This gene may play roles in the development of skeleton, kidney and lung, and is considered to be a plausible candidate gene for High Bone Mass Syndrome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

354 residues, UniProt reviewed canonical sequence.

>O96014|WNT11
     1  MRARPQVCEA LLFALALQTG VCYGIKWLAL SKTPSALALN QTQHCKQLEG LVSAQVQLCR
    61  SNLELMHTVV HAAREVMKAC RRAFADMRWN CSSIELAPNY LLDLERGTRE SAFVYALSAA
   121  AISHAIARAC TSGDLPGCSC GPVPGEPPGP GNRWGGCADN LSYGLLMGAK FSDAPMKVKK
   181  TGSQANKLMR LHNSEVGRQA LRASLEMKCK CHGVSGSCSI RTCWKGLQEL QDVAADLKTR
   241  YLSATKVVHR PMGTRKHLVP KDLDIRPVKD SELVYLQSSP DFCMKNEKVG SHGTQDRQCN
   301  KTSNGSDSCD LMCCGRGYNP YTDRVVERCH CKYHWCCYVT CRRCERTVER YVCK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against WNT11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
36 nTPM

Expression across tissuesHPA

Tissue

  • adipose tissue: 36 nTPM
  • breast: 24 nTPM
  • adrenal gland: 21 nTPM
  • thyroid gland: 16 nTPM
  • choroid plexus: 13 nTPM
  • skeletal muscle: 12 nTPM

Single-cell type

  • fibro-adipogenic progenitors: 35 nCPM
  • platelets: 25 nCPM
  • fibroblasts: 17 nCPM
  • adrenal cortex cells: 14 nCPM
  • megakaryocytes: 12 nCPM
  • cardiomyocytes: 9.6 nCPM

Immune cell

  • NK-cell: 2.9 nTPM
  • eosinophil: 0.4 nTPM
  • MAIT T-cell: 0.4 nTPM
  • total PBMC: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM

Brain region

  • choroid plexus: 30 nTPM
  • pons: 15 nTPM
  • medulla oblongata: 13 nTPM
  • cerebellum: 8.6 nTPM
  • hippocampal formation: 7.8 nTPM
  • hypothalamus: 7.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.81
gnomAD pLI
0.01
gnomAD missense Z
1.41
DepMap mean gene effect
-0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads WNT11 as an antibody target. Whether an autoantibody or antibody against WNT11 could matter depends on whether native WNT11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

WNT11 is annotated as secreted, so native WNT11 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label WNT11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/WNT11. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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