Seroatlas · Human Serome Atlas

WHR1

Winged helix repair factor 1

Also known as: D6S60, G11, RP1, STK19, WHR1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P49842
Gene
WHR1
Ensembl
ENSG00000204344
Chromosome
6
Canonical length
254 aa
Protein class
Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins
Subcellular location
Nuclear speckles
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a serine/threonine kinase which localizes predominantly to the nucleus. Its specific function is unknown; it is possible that phosphorylation of this protein is involved in transcriptional regulation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6 and expresses two transcript variants. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

254 residues, UniProt reviewed canonical sequence.

>P49842|WHR1
     1  MSWKRHHLIP ETFGVKRRRK RGPVESDPLR GEPGSARAAV SELMQLFPRG LFEDALPPIV
    61  LRSQVYSLVP DRTVADRQLK ELQEQGEIRI VQLGFDLDAH GIIFTEDYRT RVLKACDGRP
   121  YAGAVQKFLA SVLPACGDLS FQQDQMTQTF GFRDSEITHL VNAGVLTVRD AGSWWLAVPG
   181  AGRFIKYFVK GRQAVLSMVR KAKYRELLLS ELLGRRAPVV VRLGLTYHVH DLIGAQLVDC
   241  ISTTSGTLLR LPET

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against WHR1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
9.6 nTPM

Expression across tissuesHPA

Tissue

  • pancreas: 9.6 nTPM
  • choroid plexus: 7.6 nTPM
  • salivary gland: 6.2 nTPM
  • ovary: 6.1 nTPM
  • skin: 5.8 nTPM
  • esophagus: 5.3 nTPM

Single-cell type

  • late spermatids: 22 nCPM
  • early spermatids: 20 nCPM
  • proximal tubule cells: 19 nCPM
  • podocytes: 14 nCPM
  • renal collecting duct principal cells: 12 nCPM
  • bergmann glia: 12 nCPM

Immune cell

  • basophil: 12 nTPM
  • eosinophil: 8.5 nTPM
  • classical monocyte: 6.8 nTPM
  • myeloid DC: 6.3 nTPM
  • gdT-cell: 6.1 nTPM
  • naive B-cell: 5.5 nTPM

Brain region

  • cerebral cortex: 6.5 nTPM
  • white matter: 6.5 nTPM
  • thalamus: 6.3 nTPM
  • spinal cord: 5.5 nTPM
  • basal ganglia: 5.3 nTPM
  • pons: 5.3 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about WHR1.

Disease | ImmuneIEDB

Conditions an epitope on WHR1 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.7
gnomAD pLI
0
DepMap mean gene effect
-0.07
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 20% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Inactive serine/threonine-protein kinase 19-like
  • Inactive serine-threonine protein kinase 19

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads WHR1 as an antibody target. Whether an autoantibody or antibody against WHR1 could matter depends on whether native WHR1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

WHR1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label WHR1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/WHR1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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